Asthma Treatment Outcome Measures

  • Manisha WitmansEmail author


Asthma is a common, systemic chronic inflammatory disease characterized by reversible lower airflow obstruction affecting over 334 million people worldwide and is the most common chronic disease in children. Asthma is influenced by genetic and environmental factors in its presentation in affected individuals. Whether allergies play a role or not, the inflammation in the airway is the pathophysiological mechanism and target of treatment to not only control the symptoms but also the inflammatory cascade that results from the trigger that initiated the response. In the last decade, it has become apparent that asthma is also a risk factor for obstructive sleep disordered breathing (pediatric OSA) and vice versa. Additional burden from inflammation associated with obesity further contributes to the problem and may be an accelerant of systemic inflammation. The role of inflammation within the airway systemically has widespread systemic effects for childhood development, growth, and functioning. As much as allergies affect sleep quality and can be a risk factor for the presence of pediatric OSA, the role of fragmented sleep may equally affect the presence of inflammatory cytokines both in the airway and systemically. The aim of this chapter is to discuss the role of treatment outcome measures in asthma and how that may determine future management of asthma, allergies, and sleep problems in affected individuals.


Asthma outcome measures Pediatric obstructive sleep disordered breathing (pediatric OSA) Atopic disease Anti-inflammatory therapy in asthma Medications for asthma 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Pediatric Pulmonology, Department of PediatricsThe Stollery Children’s Hospital & University of Alberta HospitalsEdmontonCanada

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