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Deleterious Consequences of Dietary Advanced Glycation End Products on Human Health Due to Oxidative Stress and Inflammation

  • Suresh D. SharmaEmail author
  • Michele Barone
Chapter
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Abstract

The evolution of modern food productions has progressively modified dietary patterns in the industrialised world with the increase of chronic diseases. The technological progress in food industries might be roughly correlated with the concomitant augment and differentiation of certain diseases. The diversification of the problem has to be expected because foods and beverages imply a multidisciplinary knowledge, including microbiological causes and effects, chemical and physical features, technological factors also linked to the First and the Second Laws of Food Degradation, nutritional and hedonistic behaviours, and public health. The aim of this chapter is to describe one of the most interesting issues correlated to foods normally containing ‘Maillard reaction products’: the production of advanced glycation products. High levels of these complex compounds are reported in relation with chronic diseases (renal failure, diabetes, oxidative stress, inflammation, etc.). Because of the strict relationship between the observed increase of glycation end products and thermal food processing, the chemical identification and quantification of these compounds in foods are extremely useful. In addition, this chapter described some possible solutions and health guidelines for consumers against deleterious effects represented by advanced glycation products.

Keywords

Advanced glycation end product Aminoguanidine Chronic disease Diabetes Pyridoxamine Retinopathy Vitamin C 

Abbreviations

AGE

Advanced glycation end product

FAO

Food and Agriculture Organization of the United Nations

GOLD

Glyoxal–lysine dimer

MRP

Maillard reaction product

MOLD

Methylglyoxal–lysine dimer

CML

N-ε-(carboxymethyl)lysine

ROS

Reactive oxygen species

RAGE

Receptor for AGE

WHO

World Health Organization

References

  1. Ahmed N (2005) Advanced glycation endproducts-role in pathology of diabetic complications. Diab Res Clin Pract 67(1):3–21.  https://doi.org/10.1016/j.diabres.2004.09.004CrossRefGoogle Scholar
  2. Ahmed MU, Brinkmann Frye E, Degenhardt TP, Thorpe SR, Baynes JW (1997) N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens protein. Biochem J 324(2):565–570.  https://doi.org/10.1042/bj3240565CrossRefPubMedPubMedCentralGoogle Scholar
  3. ALjahdali N, Carbonero F (2017) Impact of Maillard reaction products on nutrition and health: Current knowledge and need to understand their fate in the human digestive system. Crit Rev Food Sci Nutr, 1–14.  https://doi.org/10.1080/10408398.2017.1378865CrossRefGoogle Scholar
  4. Anjali Jain A (2004) Fighting obesity. BMJ 328:1327.  https://doi.org/10.1136/bmj.328.7452.1327CrossRefPubMedPubMedCentralGoogle Scholar
  5. Bakris GL, Bank AJ, Kass DA, Neutel JM, Preston RA, Oparil S (2004) Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. Am J Hypertens 17(12):23S–30S.  https://doi.org/10.1016/j.amjhyper.2004.08.022CrossRefGoogle Scholar
  6. Barbera M, Gurnari G (2017) Wastewater treatment and reuse in the food industry. Springer International Publishing, ChamGoogle Scholar
  7. Baynes JW (2002) The Maillard hypothesis on aging: time to focus on DNA. Ann NY Acad Sci 959(1):360–367.  https://doi.org/10.1111/j.1749-6632.2002.tb02107.xCrossRefPubMedGoogle Scholar
  8. Brunazzi G, Parisi S, Pereno A (2014) The importance of packaging design for the chemistry of food products. Springer International Publishing, ChamCrossRefGoogle Scholar
  9. Chen HJC, Cerami A (1993) Mechanism of inhibition of advanced glycosylation by aminoguanidine in vitro. J Carbohydr Chem 12(6):731–742.  https://doi.org/10.1080/07328309308019003CrossRefGoogle Scholar
  10. Chen XM, Dai Y, Kitts DD (2016) Detection of Maillard reaction product [5-(5,6-Dihydro-4H-pyridin-3-ylidenemethyl)furan-2-yl]methanol (F3-A) in breads and demonstration of bioavailability in Caco-2 intestinal cells. J Agric Food Chem 64(47):9072–9077.  https://doi.org/10.1021/acs.jafc.6b0436CrossRefPubMedGoogle Scholar
  11. Degenhardt TP, Alderson NL, Arrington DD, Beattie RJ, Basgen JM, Steffes MW, Thorpe SR, Baynes JW (2002) Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat. Kidney Int 61(3):939–950.  https://doi.org/10.1046/j.1523-1755.2002.00207.xCrossRefPubMedGoogle Scholar
  12. Delgado-Andrade C (2014) Maillard reaction products: some considerations on their health effects. Clin Chem Lab Med 52(1):53–60.  https://doi.org/10.1515/cclm-2012-0823CrossRefPubMedGoogle Scholar
  13. Devcich DA, Pedersen IK, Petrie KJ (2007) You eat what you are: modern health worries and the acceptance of natural and synthetic additives in functional foods. Appet 48(3):333–337.  https://doi.org/10.1016/j.appet.2006.09.014CrossRefGoogle Scholar
  14. Dyer DG, Dunn JA, Thorpe SR, Bailie KE, Lyons TJ, McCance DR, Baynes JW (1993) Accumulation of Maillard reaction products in skin collagen in diabetes and aging. J Clin Invest 91(6):2463–2469CrossRefGoogle Scholar
  15. Edelstein D, Brownlee M (1992) Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine. Diabetes 41(1):26–29.  https://doi.org/10.2337/diab.41.1.26CrossRefPubMedGoogle Scholar
  16. Friedman M (2003) Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem 51:4504–4526.  https://doi.org/10.1021/jf030204+CrossRefPubMedGoogle Scholar
  17. Fu MX, Wells-Knecht KJ, Blackledge JA, Lyons TJ, Thorpe SR, Baynes JW (1994) Glycation, glycoxidation, and cross-linking of collagen by glucose: kinetics, mechanisms, and inhibition of late stages of the Maillard reaction. Diabetes 43(5):676–683.  https://doi.org/10.2337/diab.43.5.676CrossRefPubMedGoogle Scholar
  18. Gkogkolou P, Böhm M (2012) Advanced glycation end products: key players in skin aging? Derm Endocrinol 4(3):259–270.  https://doi.org/10.4161/derm.22028CrossRefGoogle Scholar
  19. Gurnari G (2015) Safety protocols in the food industry and emerging concerns. Springer International Publishing, ChamCrossRefGoogle Scholar
  20. Hayase F, Usui T, Nishiyama K, Sasaki S, Shirahashi Y, Tsuchiya N, Numata N, Watanabe H (2005) Chemistry and biological effects of melanoidins and glyceraldehyde-derived pyridinium as advanced glycation end products. Ann NY Acad Sci 1043(1):104–1010.  https://doi.org/10.1196/annals.1333.013CrossRefPubMedGoogle Scholar
  21. Hellwig M, Bunzel D, Huch M, Franz CMAP, Kulling SE, Henle T (2015) Stability of individual Maillard reaction products in the presence of the human colonic microbiota. J Agric Food Chem 63(30):6723–6730.  https://doi.org/10.1021/acs.jafc.5b01391CrossRefPubMedGoogle Scholar
  22. Henle T (2008) Maillard reaction of proteins and advanced glycation end products (AGEs) in food. In: Stadler RH, Lineback DR (eds) Process-induced food toxicants: occurrence, formation, mitigation, and health risks. Wiley, Hoboken.  https://doi.org/10.1002/9780470430101.ch2g
  23. Hirsch J, Petrakova E, Feather MS (1992) The reaction of some dicarbonyl sugars with aminoguanidine. Carbohydr Res 232(1):125–130.  https://doi.org/10.1016/s0008-6215(00)90999-6CrossRefPubMedGoogle Scholar
  24. Hong H (2016) Modern industrial foods and their effects on the human body. Nat Med J 8, 4. Available https://www.naturalmedicinejournal.com/journal/2016-04/modern-industrial-foods-and-their-effects-human-body. Accessed 29 Oct 2018
  25. Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M (2010) Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: role of macrophage scavenger receptor class A type I and II. J Allergy Clin Immunol 125(1):175–183.  https://doi.org/10.1016/j.jaci.2009.08.013CrossRefPubMedGoogle Scholar
  26. John WG, Lamb EJ (1993) The Maillard or browning reaction in diabetes. Eye (London) 7(Pt 2):230–237.  https://doi.org/10.1038/eye.1993.55CrossRefGoogle Scholar
  27. Kirkland JL (2002) The biology of senescence: potential for prevention of disease. Clin Geriatr Med 18(3):383–405.  https://doi.org/10.1016/s0749-0690(02)00023-xCrossRefPubMedGoogle Scholar
  28. Kokkinidou S (2013) Inhibition of Maillard reaction pathways and off-flavor development in UHT milk: structure reactivity of phenolic compounds. Dissertation, University of Minnesota, MinneapolisGoogle Scholar
  29. Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H (1997) Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 94(12):6474–6479.  https://doi.org/10.1073/pnas.94.12.6474CrossRefPubMedGoogle Scholar
  30. Löbner J, Degen J, Henle T (2015) Creatine Is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-Methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr). J Agric Food Chem 63(8):2249–2256.  https://doi.org/10.1021/jf505998zCrossRefPubMedGoogle Scholar
  31. Lobo V, Patil A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4(8):118–126.  https://doi.org/10.4103/0973-7847.70902CrossRefPubMedPubMedCentralGoogle Scholar
  32. Lund MN, Ray CA (2017) Control of Maillard reactions in foods: strategies and chemical mechanisms. J Agric Food Chem 65(23):4537–4552.  https://doi.org/10.1021/acs.jafc.7b00882CrossRefPubMedGoogle Scholar
  33. Lyons TJ, Bailie KE, Dyer DG, Dunn JA, Baynes JW (1991) Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus. J Clin Invest 87(6):1910–1915.  https://doi.org/10.1172/JCI115216CrossRefPubMedPubMedCentralGoogle Scholar
  34. Navarro M, Morales FJ (2016) In vitro investigation on the antiglycative and carbonyl trapping activities of hydroxytyrosol. Eur Food Res Technol 242(7):1101–1110.  https://doi.org/10.1007/s00217-015-2614-8CrossRefGoogle Scholar
  35. Odetti P, Aragno I, Garibaldi S, Valentini S, Pronzato MA, Rolandi R (1998) Role of advanced glycation endproducts in aging collagen. A scanning force microscope study. Gerontol 44(4):187–191.  https://doi.org/10.1159/000022008CrossRefGoogle Scholar
  36. Parisi S (2002) Profili evolutivi dei contenuti batterici e chimico-fisici in prodotti lattiero-caseari. Ind Aliment 41(412):295–306Google Scholar
  37. Parisi S (2003) Evoluzione chimico-fisica e microbiologica nella conservazione di prodotti lattiero - caseari. Ind Aliment 42(423):249–259Google Scholar
  38. Parisi S (2004) Alterazioni in imballaggi metallici termicamente processati. Gulotta Press, PalermoGoogle Scholar
  39. Parisi S (2012) Food packaging and food alterations. The user-oriented approach. Smithers Rapra Technology Ltd., ShawburyGoogle Scholar
  40. Parisi S (2013) Food industry and packaging materials. User-oriented Guidelines for Users. Smithers Rapra Technology Ltd., ShawburyGoogle Scholar
  41. Parisi S, Luo W (2018) Chemistry of Maillard reactions in processed foods. Springer International Publishing, ChamCrossRefGoogle Scholar
  42. Parisi S, Delia S, Laganà P (2004) Il calcolo della data di scadenza degli alimenti: la funzione Shelf Life e la propagazione degli errori sperimentali. Ind Aliment 43(438):735–749Google Scholar
  43. Parisi S, Laganà P, Delia S (2006) Curve di crescita dei miceti in diversi formaggi in atipiche condizioni di conservazione. Ind Aliment 45(458):532–538Google Scholar
  44. Paul RG, Bailey AJ (1996) Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol 28(12):1297–1310.  https://doi.org/10.1016/S1357-2725(96)00079-9CrossRefPubMedGoogle Scholar
  45. Peppa M, Brem H, Ehrlich P, Zhang JG, Cai W, Li Z, Croitoru A, Thung S, Vlassara H (2003) Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 52(11):2805–2813.  https://doi.org/10.2337/diabetes.52.11.2805CrossRefPubMedGoogle Scholar
  46. Petersen L, Søe JB (2002) A process for the prevention and/or reduction of Maillard reaction in a foodstuff containing a protein, a peptide or an amino acid and a reducing sugar. World Intellectual Property Organization Patent WO2002039828A3, 23 Mar 2002Google Scholar
  47. Popping B, Allred L, Bourdichon F, Brunner K, Diaz-Amigo C, Galan-Malo P, Lacorn M, North J, Parisi S, Rogers A, Sealy-Voyksner J, Thompson T, Yeung J (2018) Stakeholders’ guidance document for consumer analytical devices with a focus on gluten and food allergens. J AOAC 101(1):1–5.  https://doi.org/10.5740/jaoacint.17-0425CrossRefGoogle Scholar
  48. Rahbar S, Figarola JL (2003) Novel inhibitors of advanced glycation endproducts. Arch Biochem Biophys 419(1):63–79.  https://doi.org/10.1016/j.abb.2003.08.00CrossRefPubMedGoogle Scholar
  49. Raj DSC, Choudhury D, Welbourne TC, Levi M (2000) Advanced glycation end products: a nephrologist’s perspective. Am J Kidney Dis 35(3):365–380.  https://doi.org/10.1016/S0272-6386(00)70189-2CrossRefPubMedGoogle Scholar
  50. Ramasamy R, Vannucci SJ, Yan SSD, Herold K Yan SF, Schmidt AM (2005) Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiol 15(7):16R–28R.  https://doi.org/10.1093/glycob/cwi053CrossRefGoogle Scholar
  51. Sanders TAB (1999) Food production and food safety. BMJ 318(7199):1689–1693.  https://doi.org/10.1136/bmj.318.7199.1689CrossRefPubMedPubMedCentralGoogle Scholar
  52. Schleicher E, Wagner E, Nerlich A (1997) Increased accumulation of glycoxidation product carboxymethyllysine in human tissues in diabetes and aging. J Clin Invest 99(3):457–468.  https://doi.org/10.1172/jci119180CrossRefPubMedPubMedCentralGoogle Scholar
  53. Scott E (2003) Food safety and foodborne disease in 21st century homes. Can J Infect Dis 14(5):277–280.  https://doi.org/10.1155/2003/363984CrossRefPubMedPubMedCentralGoogle Scholar
  54. Šebeková K, Saavedra G, Zumpe C, Somoza V, Klenovicsová K, Birlouez-Aragon I (2008) Plasma concentration and urinary excretion of Nɛ-(Carboxymethyl)lysine in breast milk- and formula-fed infants. Ann NY Acad Sci 1126(1):177–180.  https://doi.org/10.1196/annals.1433.049CrossRefPubMedGoogle Scholar
  55. Seiquer I, Rubio LA, Peinado MJ, Delgado-Andrade C, Navarro MP (2014) Maillard reaction products modulate gut microbiota composition in adolescents. Mol Nutr Food Res 58(7):1552–1560.  https://doi.org/10.1002/mnfr.201300847CrossRefPubMedGoogle Scholar
  56. Simpson BK (2012) Food biochemistry and food processing, 2nd edn. Wiley-Blackwell, AmesGoogle Scholar
  57. Singh R, Barden A, Mori T, Beilin L (2001) Advanced glycation end-products: a review. Diabetologia 44(2):129–146.  https://doi.org/10.1007/s001250051591CrossRefPubMedGoogle Scholar
  58. Singla RK, Dubey AK, Ameen SM, Montalto S, Parisi S (2018) Analytical methods for the assessment of Maillard reactions in foods. Springer International Publishing, ChamCrossRefGoogle Scholar
  59. Søe JB, Petersen LW (2005) Methods of reducing or preventing Maillard reactions in potato with hexose oxidase. US Patent 6,872,412 B2, 29 Mar 2005Google Scholar
  60. Tessier FJ, Jacolot P, Niquet-Leridon C (2014) Research commentaries for the members of the international Maillard reaction society: open questions around the carboxymethyllysine. IMARS Highlights 9(3):14–20Google Scholar
  61. Thorpe SR, Baynes JW (2003) Maillard reaction products in tissue proteins: new products and new perspectives. Amino Acids 25(3–4):275–281.  https://doi.org/10.1007/s00726-003-0017-9CrossRefPubMedGoogle Scholar
  62. Toda M, Heilmann M, Ilchmann A, Vieths S (2014) The Maillard reaction and food allergies: is there a link? Clin Chem Lab Med 52(1):61–67.  https://doi.org/10.1515/cclm-2012-0830CrossRefPubMedGoogle Scholar
  63. Totlani VM, Peterson DG (2005) Reactivity of epicatechin in aqueous glycine and glucose Maillard reaction models: Quenching of C2, C3, and C4 sugar fragments. J Agric Food Chem 53(10):4130–4135.  https://doi.org/10.1021/jf050044xCrossRefPubMedGoogle Scholar
  64. Traverso N, Menini S, Maineri EP, Patriarca S, Odetti P, Cottalasso D, Marinari UM, Pronzato MA (2004) Malondialdehyde, a lipoperoxidation-derived aldehyde, can bring about secondary oxidative damage to proteins. J Gerontol Series A: Biol Sci Med Sci 59(9):B890–B895.  https://doi.org/10.1093/gerona/59.9.b890CrossRefGoogle Scholar
  65. Troise AD, Dathan NA, Fiore A, Roviello G, Di Fiore A, Caira S, Cuollo M, De Simone G, Fogliano V, Monti SM (2013) Faox enzymes inhibited Maillard reaction development during storage both in protein glucose model system and low lactose UHT milk. Amino Acids 46(2):279–288.  https://doi.org/10.1007/s00726-013-1497-xCrossRefPubMedGoogle Scholar
  66. Trowell H (1972) Ischemic heart disease and dietary fiber. Am J Clin Nutr 25(9):926–932.  https://doi.org/10.1093/ajcn/25.9.926CrossRefPubMedGoogle Scholar
  67. Urribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H (2005) Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann NY Acad Sci 1043(1):461–466.  https://doi.org/10.1196/annals.1333.052CrossRefGoogle Scholar
  68. Van Nguyen C (2006) Toxicity of the AGEs generated from the Maillard reaction: on the relationship of food-AGEs and biological-AGEs. Mol Nutr Food Res 50(12):1140–1149.  https://doi.org/10.1002/mnfr.200600144CrossRefGoogle Scholar
  69. Vasan S, Foiles P, Founds H (2003) Therapeutic potential of breakers of advanced glycation end product- protein crosslinks. Arch Biochem Biophys 419(1):89–96.  https://doi.org/10.1016/j.abb.2003.08.016CrossRefPubMedGoogle Scholar
  70. Vlassara H (2005) Advanced glycation in health and disease: role of the modern environment. Ann NY Acad Sci 1043(1):452–460.  https://doi.org/10.1196/annals.1333.051CrossRefPubMedGoogle Scholar
  71. Vlassara H, Striker GE (2011) AGE restriction in diabetes mellitus: a paradigm shift. Nat Rev Endocrinol 7(9):526–539.  https://doi.org/10.1038/nrendo.2011.74CrossRefPubMedPubMedCentralGoogle Scholar
  72. Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield EJ (2002) Nonlinear partial differential equations and applications: Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 99(24):15596–15601.  https://doi.org/10.1073/pnas.242407999CrossRefPubMedGoogle Scholar
  73. Voziyan PA, Hudson BG (2005) Pyridoxamine: the many virtues of a Maillard reaction inhibitor. Ann NY Acad Sci 1043(1):807–816.  https://doi.org/10.1196/annals.1333.093CrossRefPubMedGoogle Scholar
  74. WHO/FAO (2003) Diet, nutrition and the prevention of chronic diseases. Report of a joint WHO/ FAO expert consultation. WHO technical report series No 916. World Health Organization (WHO), Geneva, and Food and Agriculture Organization of the United Nations (FAO), RomeGoogle Scholar
  75. Yamagishi S, Ueda S, Okuda S (2007) Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders. Curr Pharm Des 13(27):2832–2836.  https://doi.org/10.2174/138161207781757051CrossRefPubMedGoogle Scholar
  76. Zhang Q, Ames JM, Smith RD, Baynes JW, Metz TO (2008) A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: probing the pathogenesis of chronic disease. J Proteom Res 8(2):754–769.  https://doi.org/10.1021/pr800858hCrossRefGoogle Scholar

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© The Author(s), under exclusive license to Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyPennsylvania State UniversityUniversity Park, State CollegeUSA
  2. 2.Associazione “Componiamo il Futuro” (CO.I.F.)PalermoItaly

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