Genetic Basis of Dental Caries and Periapical Pathology

  • Alexandre Rezende Vieira


Dental caries is a disease consequence of continued localized mineral loss from the dental enamel. As it progresses, subclinical mineral losses become visible (white spot lesions) and eventually unsupported enamel collapses (cavitates). Historically caries has been treated by a classical surgical approach implemented by dentists over the decades. As care shifts toward a holistic medical approach, one challenge in communicating the need for this shift is that we use the same term “dental caries” to indicate both the disease and its consequences: the carious lesions. Dental caries requires a susceptible host. The factors involved with the host include the status of the dentition, saliva and immune response, and behaviors. These factors are influenced by genetics and dental caries can be said to have a multifactorial or complex mode of inheritance, with environmental factors likely overturning any individual susceptibility to the condition.


Dental caries Tooth demineralization Dental pulp diseases Pulpitis Tooth, nonvital Toothache Tooth loss Genetics Heredity 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alexandre Rezende Vieira
    • 1
  1. 1.Oral BiologyUniversity of PittsburghPittsburghUSA

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