Coats Disease

  • Ulrich Spandau
  • Sang Jin Kim


This chapter is about Coats disease. The diagnosis and classification of Coats disease is explained and illustrated with many pictures.


Coats Coats disease Classification Diagnosis 


  1. 1.
    Coats G. Forms of retinal diseases with massive exudation. Graefes Arhiv für Ophthalmologie. 1912;17:440–525.Google Scholar
  2. 2.
    Blair MP, Ulrich JN, Elizabeth Hartnett M, Shapiro MJ. Peripheral retinal nonperfusion in fellow eyes in coats disease. Retina. 2013;33:1694–9.CrossRefGoogle Scholar
  3. 3.
    Jung EH, Kim JH, Kim SJ, Yu YS. Fluorescein angiographic abnormalities in the contralateral eye with Normal fundus in children with unilateral Coats’ disease. Korean J Ophthalmol. 2018;32:65–9.CrossRefGoogle Scholar
  4. 4.
    Kase S, Rao NA, Yoshikawa H, Fukuhara J, Noda K, Kanda A, Ishida S. Expression of vascular endothelial growth factor in eyes with Coats’ disease. Invest Ophthalmol Vis Sci. 2013;54:57–62.CrossRefGoogle Scholar
  5. 5.
    Black GC, Perveen R, Bonshek R, Cahill M, Clayton-Smith J, Lloyd IC, McLeod D. Coats’ disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis. Hum Mol Genet. 1999;8:2031–5.CrossRefGoogle Scholar
  6. 6.
    Hasan SM, Azmeh A, Mostafa O, Megarbane A. Coat’s like vasculopathy in leber congenital amaurosis secondary to homozygous mutations in CRB1: a case report and discussion of the management options. BMC Res Notes. 2016;9:91.CrossRefGoogle Scholar
  7. 7.
    Gupta MP, Talcott KE, Kim DY, Agarwal S, Mukai S. Retinal findings and a novel TINF2 mutation in Revesz syndrome: clinical and molecular correlations with pediatric retinal vasculopathies. Ophthalmic Genet. 2017;38:51–60.CrossRefGoogle Scholar
  8. 8.
    Sohn EH, Michaelides M, Bird AC, Roberts CJ, Moore AT, Smyth D, Brady AF, Hungerford JL. Novel mutation in PANK2 associated with retinal telangiectasis. Br J Ophthalmol. 2011;95:149–50.CrossRefGoogle Scholar
  9. 9.
    Saatci AO, Ayhan Z, Yaman A, Bora E, Ulgenalp A, Kavukcu S. A 12-year-old girl with bilateral Coats disease and ABCA4 gene mutation. Case Rep Ophthalmol. 2018;9:375–80.CrossRefGoogle Scholar
  10. 10.
    Shields JA, Shields CL, Honavar SG, Demirci H, Cater J. Classification and management of Coats disease: the 2000 Proctor Lecture. Am J Ophthalmol. 2001;131:572–83.CrossRefGoogle Scholar
  11. 11.
    Sigler EJ, Randolph JC, Calzada JI, Wilson MW, Haik BG. Current management of Coats disease. Surv Ophthalmol. 2014;59:30–46.CrossRefGoogle Scholar
  12. 12.
    Shields JA, Shields CL, Honavar SG, Demirci H. Clinical variations and complications of Coats disease in 150 cases: the 2000 Sanford Gifford Memorial Lecture. Am J Ophthalmol. 2001;131:561–71.CrossRefGoogle Scholar
  13. 13.
    Levinson JD, Hubbard GB 3rd. 577-nm yellow laser photocoagulation for Coats disease. Retina. 2016;36:1388–94.CrossRefGoogle Scholar
  14. 14.
    Ong SS, Buckley EG, McCuen BW 2nd, Jaffe GJ, Postel EA, Mahmoud TH, Stinnett SS, Toth CA, Vajzovic L, Mruthyunjaya P. Comparison of visual outcomes in Coats’ disease: a 20-year experience. Ophthalmology. 2017;124:1368–76.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ulrich Spandau
    • 1
  • Sang Jin Kim
    • 2
  1. 1.OphthalmologyUniversity of Uppsala OphthalmologyUppsalaSweden
  2. 2.Department of OphthalmologySamsung Medical Center, Sungkyunkwan UniversitySeoulSouth Korea

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