Locorregional Treatment in Patients with Metastatic Breast Cancer

  • BBSG – Brazilian Breast Study Group


Local treatment using surgery with or without radiotherapy in patients with metastatic breast cancer has always been reserved for extreme situations of locally advanced lesions, with the objective of symptom palliative measures (“hygienic” surgery).


Metastatic breast cancer De novo stage IV breast cancer Surgery of primary Locoregional treatment Oncologic outcomes 

Recommended Reading

  1. 1.
    Badwe R, Hawaldar R, Nair N, Kaushik R, Parmar V, Siddique S, et al. Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial. Lancet Oncol. 2015;16(13):1380–8. Publication of the Indian study. Google Scholar
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    Fitzal F, Balic M, Bjelic-Radisic V, Hubalek M, Singer CF, et al. Primary operation in synchroneous metastasized invasive breast cancer patients: first oncologic outcomes of the prospective randomized phase III ABCSG 28 POSYTIVE trial. ASCO 2017 – oral presentation. Oral presentation of the Austrian study at ASCO 2017.
  3. 3.
    Khan SA. Surgical management of de novo Stage IV breast cancer. Seminars Radiat Oncol. 2016;26:79–86. Review on the role of surgery in metastatic breast cancer. CrossRefGoogle Scholar
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    Petrelli F, Barni S. Surgery of primary tumors in stage IV breast cancer: an updated meta-analysis of published studies with meta-regression. Med Oncol. 2012;29(5):3282–90. Metanalysis of the main retrospective studies about the impact of surgery on prognosis. The assessed studies clearly showed the choice for the best cases for indication of surgery. CrossRefGoogle Scholar
  5. 5.
    Soran A, Ozmen A, Ozbas S, Karanlik H, Muslumanoglu M, Igci A et al. A randomized controlled trial evaluating resection of the primary breast tumor in women presenting with de novo stage IV breast cancer: Turkish Study (Protocol MF07–01). ASCO 2016 – oral presentation. Oral presentation of the Turkish study at ASCO 2016.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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