Multifocal, Multicentric, and Bilateral Carcinoma

  • BBSG – Brazilian Breast Study Group


Multicentricity is defined by some authors as two of more foci located in different quadrants or 5 cm away from each other, but inside the same quadrant. Other authors also define tumors of different genetic clones or separated by normal mammary tissue.


Multifocality Multicentricity Bilateral breast cancer Magnetic resonance imaging Conservative surgery 

Recommended Reading

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    Houssami N, et al. Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer. Breast Cancer Res Treat. 2017. Meta-analysis including 19 studies on the evaluation of preoperative magnetic resonance imaging and surgical results. By increasing this preoperative evaluation the chances of ipsilateral and contralateral mastectomy also go up. Google Scholar
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    Iacconi C, Galman L, Zheng J, et al. Multicentric cancer detected at breast MR imaging and not at mammography: important or not? Radiology. 2016;279(2):378–84. Retrospective study of 73 patients with multicentricity diagnosed only through resonance. In 75% of cases, they were invasive carcinomas and in 25% of cases they were larger than 1.0 cm. CrossRefGoogle Scholar
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    Lyman GH, Temin S, Edge SB, et al. American Society of Clinical Oncology Clinical Practice. Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2014;32(13):1365. Guideline of the American Society of Clinical Oncology, guiding the accomplishment of sentinel lymph node resection in multicentric tumors. CrossRefGoogle Scholar
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    Nijenhuis MV, Rutgers EJ. Conservative surgery for multifocal/multicentric breast cancer. Breast. 2015;24(Suppl 2):S96–9. Treatment of multicentric tumor with conservative surgery (CS), chemo-neoadjuvant and radiotherapy results in low rates of local recurrence. CS may be indicated in patients who are eligible for CS criteria and with satisfactory aesthetic results. CrossRefGoogle Scholar
  5. 5.
    Vera-Badillo FE, et al. Effect of multifocality and multicentricity on outcome in early stage breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2014;146(2):235–44. Epub 2014 Jun 14. Meta-analysis including 22 studies, with 67,577 women; 9.5% of multicentric tumors were found. In univariate analysis, multicentricity presents worse overall survival, disease-free interval, and local recurrence in 5 years CrossRefPubMedGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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