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Interactions of Nanoparticles with Skin

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Biological Responses to Nanoscale Particles

Part of the book series: NanoScience and Technology ((NANO))

Abstract

The interactions of nanoparticles with skin and skin cells are complex and depend on the nanoparticle type. The present work provides an overview on the interactions between solid nanoparticles including silica, titanium dioxide, and silver particulates and skin and skin cells on the basis of previous research results. Generally, nanoparticles applied to skin tend to remain on the skin surface and penetrate only into the upper layers of the stratum corneum and the follicular ducts. In very few cases, nanoparticles have been found in deeper skin layers, particularly if the skin barrier was previously disrupted. Increased nanoparticle penetration may result in biologically relevant effects, e.g. cytotoxic cellular effects induced by silver ions released from wound dressings incorporating silver nanoparticles.

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Acknowledgements

We thankfully acknowledge the Deutsche Forschungsgemeinschaft for their support of the Priority Program SPP 1313 “Biological Responses to Nanoscale Particles”.

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Authors and Affiliations

  1. Department of Dermatology, Venerology and Allergology, Charité – Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany

    Fanny Knorr, Alexa Patzelt, Martina Claudia Meinke, Anika Vogt, Ulrike Blume-Peytavi & Jürgen Lademann

  2. Physical Chemistry, Institute of Chemistry and Biochemistry, Free University of Berlin, Takustrasse 3, 14195, Berlin, Germany

    Eckart Rühl

Authors
  1. Fanny Knorr
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  2. Alexa Patzelt
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  3. Martina Claudia Meinke
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  5. Ulrike Blume-Peytavi
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  6. Eckart Rühl
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  7. Jürgen Lademann
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Correspondence to Jürgen Lademann .

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Editors and Affiliations

  1. Institute of Anatomy, University of Bern, Bern, Switzerland

    Peter Gehr

  2. Institute of Physical Chemistry, University of Duisburg-Essen, Essen, Germany

    Reinhard Zellner

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Knorr, F. et al. (2019). Interactions of Nanoparticles with Skin. In: Gehr, P., Zellner, R. (eds) Biological Responses to Nanoscale Particles. NanoScience and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-12461-8_13

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