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Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells

  • Yong-Xiao Wang
  • Lan Wang
  • Yun-Min ZhengEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1131)

Abstract

All seven canonical transient potential receptor (TRPC1–7) channel members are expressed in mammalian airway smooth muscle cells (ASMCs). Among this family, TRPC3 channel plays an important role in the control of the resting [Ca2+]i and agonist-induced increase in [Ca2+]i. This channel is significantly upregulated in molecular expression and functional activity in airway diseases. The upregulated channel significantly augments the resting [Ca2+]i and agonist-induced increase in [Ca2+]i, thereby exerting a direct and essential effect in airway hyperresponsiveness. The increased TRPC3 channel-mediated Ca2+ signaling also results in the transcription factor nuclear factor-κB (NF-κB) activation via protein kinase C-α (PKCα)-dependent inhibitor of NFκB-α (IκBα) and calcineurin-dependent IκBβ signaling pathways, which upregulates cyclin-D1 expression and causes cell proliferation, leading to airway remodeling. TRPC3 channel may further interact with intracellular release Ca2+ channels, Orai channels and Ca2+-sensing stromal interaction molecules, mediating important cellular responses in ASMCs and the development of airway diseases.

Keywords

Canonical transient potential receptor channel Inositol 1,4,5-trisphosphate receptor Ryanodine receptor Orai channel Stromal interaction molecule Nuclear factor κB Protein kinase C Calcineurin Airway hyperresponsiveness Airway remodeling Airway diseases 

Abbreviations

[Ca2+]i

Intracellular Ca2+ concentration

ASMCs

Airway smooth muscle cells

COPD

chronic obstructive pulmonary disease

DAG

Diacylglycerol

GPCR

G protein-coupled receptor

IP3

Inositol 1,4,5-trisphosphate

IP3R

IP3 receptor

IκB

Nuclear factor κB inhibitor

JNK

Jun amino-terminal kinase

mAch

Methacholine

NF-κB

Nuclear factor κB

NPo

Open probability

NSCC

Non-selective cation channel

OAG

1-oleoyl-2-acetyl-sn-glycerol

PIP2

Phosphatidylinositol 4,5-bisphosphate

PKCα

Protein kinase C-α

PLC

Phospholipase C

RyR

Ryanodine receptor

SOCE

Store-operated Ca2+ entry

SR

Sarcoplasmic reticulum

STIM

Stromal interaction molecule

TNFα

Tumor necrosis factor-α

TRPC

Canonical transient potential receptor

Vm

Membrane potential

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Authors and Affiliations

  1. 1.Department of Molecular and Cellular PhysiologyAlbany Medical CollegeAlbanyUSA
  2. 2.Department of Cardiopulmonary Circulation, Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina

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