Sphenopalatine Ganglion Block

  • Mark N. Malinowski
  • Nicholas J. Bremer


The sphenopalatine ganglion is a structure that has been implicated in the mediation of headache and facial pain for many decades. The neuralgia of this structure is part of a group of headaches known as the trigeminal autonomic cephalgias. This structure is one of only four predominantly parasympathetic ganglia within the head. Blockade of this structure may occur in three ways and can be both diagnostic and therapeutic. In addition, performing blockade of the sphenopalatine ganglion involves significant risk and must be undertaken with ample preoperative planning. Research continues to develop in the regulation of this structure to alleviate chronic headaches and facial pain in many forms.


Trigeminal autonomic cephalgia Trigeminal neuralgia Sphenopalatine ganglion Pterygopalatine fissure Headache Sphenopalatine ganglion block 

Recommended Reading

  1. 1.
    Costa A, Pucci E, Antonaci A, Sances G, Granella F, Broich G, Nappi G. The effect of intranasal cocaine and lidocaine on nitroglycerin – induced attacks in cluster headache. Cephalalgia. 2000;20(2):85–91.CrossRefGoogle Scholar
  2. 2.
    Devoghel J. Cluster headache and sphenopalatine ganglion block. Acta Anaesthaesthiol Belg. 1980;32(1):101–7.Google Scholar
  3. 3.
    Mojica J, Mo B, Ng A. Sphenopalatine ganglion block in the management of chronic headaches. Curr Pain Headache Rep. 2017;21(27):1–8.Google Scholar
  4. 4.
    Robbins M, Robertson C, Kaplan E, Ailani J, Charlston L, Kuruvilla D, Blumenfeld A, Berliner R, Rosen N, Duarte R, Vidwan J, Halker R, Gill N, Ashkenazi A. The sphenopalatine ganglion: anatomy, pathophysiology and therapeutic targeting in headache. Headache. 2016;56:240–58.CrossRefGoogle Scholar
  5. 5.
    Ruskin A. Sphenopalatine (nasal) ganglion: remote effects including “psychosomatic” symptoms, rage reaction, pain and spasm. Arch Phys Med Rehabil. 1979;60:353–9.PubMedGoogle Scholar
  6. 6.
    Sluder G. The anatomical and clinical relations of the sphenopalatine ganglion to the nose. NY State J Med. 1908;90:293–8.Google Scholar
  7. 7.
    Tepper S, Caparso A. Sphenopalatine ganglion (SPG): stimulation mechanism, safety and efficacy. Headache. 2017;57:14–28.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mark N. Malinowski
    • 1
  • Nicholas J. Bremer
    • 2
  1. 1.Adena Spine CenterChillicotheUSA
  2. 2.Center for Pain Relief, Spine and Nerve Centers of the VirginiasCharlestonUSA

Personalised recommendations