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Thymus Transcriptome of TGF-β Superfamily

  • Arnon Dias JurbergEmail author
  • Vinicius Cotta-de-AlmeidaEmail author
Chapter

Abstract

Members of the TGF-β superfamily play pleiotropic activities in the thymus, which ultimately involve epithelial cell homeostasis and proper maturation of many T cell subsets. This chapter performs a second-level analysis of thymic transcriptomes to highlight key factors and functional evidence that may be used to guide putative medical interventions for rescuing the production of a given specific T cell type.

Keywords

Thymus Thymic epithelial cell Thymocyte Lymphocyte TGF-β BMP 

Notes

Acknowledgments

This work benefited from data assembled by the ImmGen consortium. A.D.J. is supported by a fellowship from the Rio de Janeiro State Research Council/FAPERJ (E-26/202.683/2016). The work was financially supported by the Oswaldo Cruz Institute/Fiocruz, the Estacio de Sá University (Productivity in Research Program), the Brazilian National Institute of Science and Technology on Neuroimmunomodulation/INCT-NIM, MERCOSUL Fund for Structural Convergence/FOCEM, the Brazilian Research Council/CNPq, and the Rio de Janeiro State Research Council (FAPERJ).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Laboratory on Thymus Research, Oswaldo Cruz InstituteOswaldo Cruz Foundation, Pavilhão Leônidas DeaneRio de JaneiroBrazil
  2. 2.Estácio de Sá University (UNESA)Rio de JaneiroBrazil

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