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Early Intervention in Psychosis: From Science to Services

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The Palgrave Handbook of American Mental Health Policy

Abstract

Early intervention services for psychotic disorders were first tested in Australia and Europe in the 1990s. These efforts stimulated interest to develop early intervention programs in the United States and in 2016 the National Institute of Mental Health identified a treatment model called Coordinated Specialty Care (CSC). This team-based approach includes psychotherapy, medication management, family education and support, case management, and work or education support, and is the foundation for nationwide efforts to support early intervention services for individuals with a first episode psychosis (FEP). This chapter focuses on the following key policy questions related to early intervention services for FEP and in particular the CSC model: What has been the impact of CSC programs? What strategies can most effectively support implementation of these programs? How should quality of care be assessed in CSC programs? and How can they be financially sustained? For each area, specific questions are posed, prior relevant studies are summarized, and future directions for research are proposed along with recommendations for policy makers. Other key issues reviewed include the importance of decreasing the duration of untreated psychosis, whether CSC programs should be offered to clinical high-risk populations before the advent of psychosis, and strategies for sustaining good outcomes following receipt of CSC services.

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References

  1. Harding, C. M., Brooks, G. W., Ashikaga, T., Strauss, J. S., & Breier, A. (1987). The Vermont longitudinal study of persons with severe mental illness, I: Methodology, study sample, and overall status 32 years later. The American Journal of Psychiatry, 144, 718–726. https://doi.org/10.1176/ajp.144.6.718.

    Article  Google Scholar 

  2. Hegarty, J. D., Baldessarini, R. J., Tohen, M., Waternaux, C., & Oepen, G. (1994). One hundred years of schizophrenia: A meta-analysis of the outcome literature. The American Journal of Psychiatry, 151, 1409–1416. https://doi.org/10.1176/ajp.151.10.1409.

    Article  Google Scholar 

  3. McGlashan, T. H. (1988). A selective review of recent North American long-term followup studies of schizophrenia. Schizophrenia Bulletin, 14, 515–542. https://doi.org/10.1093/schbul/14.4.515.

    Article  Google Scholar 

  4. McGlashan, T. H. (1998). The profiles of clinical deterioration in schizophrenia. Journal of Psychiatric Research, 32, 133–141. https://doi.org/10.1016/S0022-3956(97)00015-0.

    Article  Google Scholar 

  5. Jääskeläinen, E., Juola, P., Hirvonen, N., McGrath, J. J., Saha, S., Isohanni, M., … Miettunen, J. (2013). A systematic review and meta-analysis of recovery in schizophrenia. Schizophrenia Bulletin, 39, 1296–1306. https://doi.org/10.1093/schbul/sbs130.

  6. Zipursky, R. B., Reilly, T. J., & Murray, R. M. (2013). The myth of schizophrenia as a progressive brain disease. Schizophrenia Bulletin, 39, 1363–1372. https://doi.org/10.1093/schbul/sbs135.

    Article  Google Scholar 

  7. Dixon, L. B., Goldman, H., Srihari, V. H., & Kane, J. M. (2018). Transforming the treatment of schizophrenia in the United States: The RAISE initiative. Annual Review of Clinical Psychology, 14, 1. https://doi.org/10.1146/annurev-clinpsy-050817-084934.

    Article  Google Scholar 

  8. Dixon, L. B., Dickerson, F., Bellack, A. S., Bennett, M., Dickinson, D., Goldberg, R. W., … Schizophrenia Patient Outcomes Research Team (PORT). (2010). The 2009 schizohprenia PORT psychosocial treatment recommendations and summary statements. Schizophrenia Bulletin, 36, 48–70. https://doi.org/10.1093/schbul/sbp115.

  9. Srihari, V. H., Tek, C., Kucukgoncu, S., Phutane, V. H., Breitborde, N. J., Pollard, J., … Woods, S. W. (2015). First-episode services for psychotic disorders in the U.S. public sector: A pragmatic randomized controlled trial. Psychiatric Services, 66, 705–712. https://doi.org/10.1176/appi.ps.201400236.

  10. Department of Health. (2000). The NHS plan: A plan for investment, a plan for reform. London: Department of Health.

    Google Scholar 

  11. Penttila, M., Jaaskelainen, E., Hirvonen, N., Isohanni, M., & Miettunen, J. (2014). Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: Systematic review and meta-analysis. The British Journal of Psychiatry, 205, 88–94. https://doi.org/10.1192/bjp.bp.113.127753.

    Article  Google Scholar 

  12. Schoenbaum, M., Sutherland, J. M., Chappel, A., Azrin, S., Goldstein, A. B., Rupp, A., & Heinssen, R. K. (2017). Twelve-month health care use and mortality in commercially insured young people with incident psychosis in the United States. Schizophrenia Bulletin, 43, 1262–1272. https://doi.org/10.1093/schbul/sbx009.

    Article  Google Scholar 

  13. Malla, A. K., Norman, R. M., & Joober, R. (2005). First-episode psychosis, early intervention, and outcome: What have we learned? Canadian Journal of Psychiatry, 50, 881–891. https://doi.org/10.1177/070674370505001402.

    Article  Google Scholar 

  14. McGorry, P. D., Edwards, J., Mihalopoulos, C., Harrigan, S. M., & Jackson, H. J. (1996). EPPIC: An evolving system of early detection and optimal management. Schizophrenia Bulletin, 22, 305–326. https://doi.org/10.1093/schbul/22.2.305.

    Article  Google Scholar 

  15. McGorry, P. D. (2004). Value of early intervention in psychosis. The British Journal of Psychiatry, 185, 172. https://doi.org/10.1192/bjp.185.2.172.

    Article  Google Scholar 

  16. Malla, A. K., Norman, R. M., Manchanda, R., McLean, T. S., Harricharan, R., Cortese, L., … Scholten, D. J. (2002). Status of patients with first-episode psychosis after one year of phase-specific community-oriented treatment. Psychiatric Services, 53, 458–463. https://doi.org/10.1176/appi.ps.53.4.458.

  17. Craig, T. K., Garety, P., Power, P., Rahaman, N., Colbert, S., Fornells-Ambrojo, M., & Dunn, G. (2004). The Lambeth Early Onset (LEO) team: Randomised controlled trial of the effectiveness of specialised care for early psychosis. British Medical Journal, 329, 1067. https://doi.org/10.1136/bmj.38246.594873.7C.

    Article  Google Scholar 

  18. Garety, P. A., Craig, T. K., Dunn, G., Fornells-Ambrojo, M., Colbert, S, Rahaman, N., … Power, P. (2006). Specialised care for early psychosis: Symptoms, social functioning and patient satisfaction: Randomised controlled trial. The British Journal of Psychiatry, 188, 37–45. https://doi.org/10.1192/bjp.bp.104.007286.

  19. Jorgensen, P., Nordentoft, M., Abel, M. B., Gouliaev, G., Jeppesen, P., & Kassow, P. (2000). Early detection and assertive community treatment of young psychotics: The Opus study rationale and design of the trial. Social Psychiatry and Psychiatric Epidemiology, 35, 283–287. https://doi.org/10.1007/s001270050240.

    Article  Google Scholar 

  20. Petersen, L., Jeppesen, P., Thorup, A., Abel, M. B., Ohlenschlaeger, J., Christensen, T. O., … Nordentoft, M. (2005). A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness. British Medical Journal, 331, 602–605. https://doi.org/10.1136/bmj.38565.415000.e01.

  21. Global Burden of Disease Study 2013 Collaborators. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 386, 743–800. https://doi.org/10.1016/S0140-6736(15)60692-4.

    Article  Google Scholar 

  22. Kane, J. M., Robinson, D. G., Schooler, N. R., Mueser, K. T., Penn, D. L., Rosenheck, R. A., … Heinssen, R. K. (2016). Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE early treatment program. American Journal of Psychiatry, 173, 362–372. https://doi.org/10.1176/appi.ajp.2015.15050632.

  23. Mueser, K. T., Penn, D. L., Addington, J., Brunette, M. F., Gingerich, S., Glynn, S. M., … Kane, J. M. (2015). The NAVIGATE program for first-episode psychosis: Rationale, overview, and description of psychosocial components. Psychiatric Services, 66, 680–690. https://doi.org/10.1176/appi.ps.201400413.

  24. Robinson, D. G., Schooler, N. R., Correll, C. U., John, M., Kurian, B. T., Marcy, P., … Kane, J. M. (2018). Psychopharmacological treatment in the RAISE-ETP study: Outcomes of a manual and computer decision support system based intervention. The American Journal of Psychiatry, 175, 169–179. https://doi.org/10.1176/appi.ajp.2017.16080919.

  25. Addington, J., Heinssen, R. K., Robinson, D. G., Schooler, N. R., Marcy, P., Brunette, M. F., … Kane, J. M. (2015). Duration of untreated psychosis in community treatment settings in the United States. Psychiatric Services, 66, 753–756. https://doi.org/10.1176/appi.ps.201400124.

  26. Dixon, L. B., Goldman, H. H., Bennett, M. E., Wang, Y., McNamara, K. A., Mendon, S. J., … Essock, S. M. (2015). Implementing coordinated specialty care for early psychosis: The RAISE connection program. Psychiatric Services, 66, 691–698. https://doi.org/10.1176/appi.ps.201400281.

  27. Nossel, I., Wall, M., Scodes, J., Marino, L., Zilkha, S., Bello, I., … Dixon, L. (2018). Outcomes and predictors in OnTrackNY, a coordinated specialty care program for early psychosis. Manuscript in preparation.

    Google Scholar 

  28. Marino, L., Nossel, I., Choi, J. C., Nuechterlein, K., Wang, Y., Essock, S., … Dixon, L. (2015). The RAISE connection program for early psychosis: Secondary outcomes and mediators and moderators of improvement. The Journal of Nervous and Mental Disease, 203, 365–371. https://doi.org/10.1097/nmd.0000000000000293.

  29. Humensky, J., Scodes, J., Wall, M., Malinovsky, I., Marino, L., Smith, T., … Dixon, L. (2017). Disability enrollment in a community-based coordinated specialty care program. The American Journal of Psychiatry, 174, 1224–1225. https://doi.org/10.1176/appi.ajp.2017.17070752.

  30. Rosenheck, R., Mueser, K. T., Sint, K., Lin, H., Lynde, D. W., Glynn, S. M., … Kane, J. M. (2017). Supported employment and education in comprehensive, integrated care for first episode psychosis: Effects on work, school, and disability income. Schizophrenia Research, 182, 120–128. https://doi.org/10.1016/j.schres.2016.09.024.

  31. Rosenheck, R. A., Estroff, S. E., Sint, K., Lin, H., Mueser, K. T., Robinson, D. G., … RAISE ETP-Investigators. (2017). Incomes and outcomes: Social Security disability benefits in first-episode psychosis. The American Journal of Psychiatry, 174, 886–894. https://doi.org/10.1176/appi.ajp.2017.16111273.

  32. Grawe, R. W., Falloon, I. R., Widen, J. H., & Skogvoll, E. (2006). Two years of continued early treatment for recent onset schizophrenia: A randomised controlled study. Acta Psychiatrica Scandinavica, 114, 328–336. https://doi.org/10.1111/j.1600-0447.2006.00799.x.

    Article  Google Scholar 

  33. Ruggeri, M., Bonetto, C., Lasalvia, A., Fioritti, A., de Girolamo, G., Santonastaso, P., … GET UP Group. (2015). Feasibility and effectiveness of a multi-element psychosocial intervention for first-episode psychosis: Results from the cluster-randomized controlled GET UP PIANO trial in a catchment area of 10 million inhabitants. Schizophrenia Bulletin, 41, 1192–1203. https://doi.org/10.1093/schbul/sbv058

  34. Fusar-Poli, P., McGorry, P. D., & Kane, J. M. (2017). Improving outcomes of first-episode psychosis: An overview. World Psychiatry, 16, 251–265. https://doi.org/10.1002/wps.20446.

    Article  Google Scholar 

  35. Anderson, K. K., Norman, R., MacDougall, A., Edwards, J., Palaniyappan, L., Lau, C., & Kurdyak, P. (2018). Effectiveness of early psychosis intervention: Comparison of service users and nonusers in population-based health administrative data. The American Journal of Psychiatry, 1–10. https://doi.org/10.1176/appi.ajp.2017.17050480.

  36. Correll, C. U., Galling, B., Pawar, A., Krivko, A., Bonetto, C., Ruggeri, M., … Kane, J. M. (2018). Comparison of early intervention services vs treatment as usual for early-phase psychosis: A systematic review, meta-analysis, and meta-regression. Journal American Medical Association Psychiatry, 75, 555–565. https://doi.org/10.1001/jamapsychiatry.2018.0623.

  37. Sigrunarson, V., Grawe, R. W., & Morken, G. (2013). Integrated treatment vs. treatment-as-usual for recent onset schizophrenia; 12 year follow-up on a randomized controlled trial. BioMed Central Psychiatry, 13, 200. https://doi.org/10.1186/1471-244x-13-200.

    Article  Google Scholar 

  38. Bertelsen, M., Jeppesen, P., Petersen, L., Thorup, A., Ohlenschlaeger, J., le Quach, P., … Nordentoft, M. (2008). Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: The OPUS trial. Archives of General Psychiatry, 65, 762–771. https://doi.org/10.1001/archpsyc.65.7.762.

  39. Secher, R. G., Hjorthoj, C. R., Austin, S. F., Thorup, A., Jeppesen, P., Mors, O., & Nordentoft, M. (2015). Ten-year follow-up of the OPUS specialized early intervention trial for patients with a first episode of psychosis. Schizophrenia Bulletin, 41, 617–626. https://doi.org/10.1093/schbul/sbu155.

    Article  Google Scholar 

  40. Chang, W. C., Kwong, V. W., Chan, G. H., Jim, O. T., Lau, E. S., Hui, C. L., … Chen, E. Y. (2016). Prediction of functional remission in first-episode psychosis: 12-month follow-up of the randomized controlled trial on extended early intervention in Hong Kong. Schizophrenia Research, 173, 79–83. https://doi.org/10.1016/j.schres.2016.03.016.

  41. Hegelstad, W. T., Larsen, T. K., Auestad, B., Evensen, J., Haahr, U., Joa, I., … McGlashan, T. (2012). Long-term follow-up of the TIPS early detection in psychosis study: Effects on 10-year outcome. The American Journal of Psychiatry, 169, 374–380. https://doi.org/10.1176/appi.ajp.2011.11030459.

  42. Albert, N., Melau, M., Jensen, H., Emborg, C., Jepsen, J. R. M., Fagerlund, B., … Nordentoft, M. (2017). Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis: Randomised, superiority, parallel group trial in Denmark (OPUS II). British Medical Journal, 356, i6681. https://doi.org/10.1136/bmj.i6681.

  43. Malla, A., Joober, R., Iyer, S., Norman, R., Schmitz, N., Brown, T., … Abadi, S. (2017). Comparing three-year extension of early intervention service to regular care following two years of early intervention service in first-episode psychosis: A randomized single blind clinical trial. World Psychiatry, 16, 278–286. https://doi.org/10.1002/wps.20456.

  44. Albert, N., Melau, M., Jensen, H., Hastrup, L. H., Hjorthøj, C., & Nordentoft, M. (2017). The effect of duration of untreated psychosis and treatment delay on the outcomes of prolonged early intervention in psychotic disorders. Nature Partner Journal Schizophrenia, 3, 34. https://doi.org/10.1038/s41537-017-0034-4.

    Article  Google Scholar 

  45. Chan, S. K. W., Chan, S. K. Y., Pang, H. H., Yan, K. K., Hui, C. L. M., Chang, W. C., … Chen, E. Y. H. (2018). Association of an early intervention service for psychosis with suicide rate among patients with first-episode schizophrenia-spectrum disorders. Journal American Medical Association Psychiatry, 75, 458–464. https://doi.org/10.1001/jamapsychiatry.2018.0185.

  46. Friis, S., Melle, I., Johannessen, J. O., Rossberg, J. I., Barder, H. E., Evensen, J. H., … McGlashan, T. H. (2016). Early predictors of ten-year course in first-episode psychosis. Psychiatric Services, 67, 438–443. https://doi.org/10.1176/appi.ps.201400558.

  47. Davidson, L., Bellamy, C., Guy, K., & Miller, R. (2012). Peer support among persons with severe mental illnesses: A review of evidence and experience. World Psychiatry, 11, 123–128. https://doi.org/10.1016/j.wpsyc.2012.05.009.

    Article  Google Scholar 

  48. Chinman, M., George, P., Dougherty, R. H., Daniels, A. S., Ghose, S. S., Swift, A., & Delphin-Rittmon, M. E. (2014). Peer support services for individuals with serious mental illnesses: Assessing the evidence. Psychiatric Services, 65, 429–441. https://doi.org/10.1176/appi.ps.201300244.

    Article  Google Scholar 

  49. Department of Health and Human Services. (n.d.). Complex technologies and therapeutics development for mental health research and practice (R43/R44). https://grants.nih.gov/grants/guide/pa-files/PA-14-197.html. Accessed November 23, 2017.

  50. Connor, C., Birchwood, M., Freemantle, N., Palmer, C., Channa, S., Barker, C., … Singh, S. (2016). Don’t turn your back on the symptoms of psychosis: the results of a proof-of-principle, quasi-experimental intervention to reduce duration of untreated psychosis. BioMed Center Psychiatry, 16, 127. https://doi.org/10.1186/s12888-016-0816-7.

  51. Lucksted, A., Essock, S. M., Stevenson, J., Mendon, S. J., Nossel, I. R., Goldman, H. H., … Dixon, L. B. (2015). Client views of engagement in the RAISE connection program for early psychosis recovery. Psychiatric Services, 66, 699–704. https://doi.org/10.1176/appi.ps.201400475.

  52. Lucksted, A., Stevenson, J., Nossel, I., Drapalski, A., Piscitelli, S., & Dixon, L. B. (2016). Family member engagement with early psychosis specialty care. Early Intervention in Psychiatry, 1–6. https://doi.org/10.1111/eip.12403.

  53. National Institute of Mental Health. (2014). Coordinated specialty care for first episode psychosis—Manual I: Outreach and recruitment. https://www.nimh.nih.gov/health/topics/schizophrenia/raise/coordinated-specialty-care-for-first-episode-psychosis-manual-i-outreach-and-recruitment.shtml. Accessed November 23, 2017.

  54. Agency for Healthcare Research and Quality. (n.d.). Consumer Assessment of Healthcare Providers and Systems (CAHPS). https://www.ahrq.gov/cahps/index.html. Accessed November 23, 2017.

  55. University of Washington Department of Psychiatry & Behavioral Sciences. (n.d.). Mental Health Statistics Improvement Program (MHSIP) Surveys. https://depts.washington.edu/pbhjp/projects-programs/page/mental-health-statistics-improvement-program-mhsip-surveys. Accessed November 23, 2017.

  56. Agency for Healthcare Research and Quality. (2016, May). Experience of Care & Health Outcomes (ECHO). https://www.ahrq.gov/cahps/surveys-guidance/echo/index.html. Accessed November 23, 2017.

  57. Simon, G. E., Stewart, C., Hunkeler, E. M., Yarborough, B. J., Lynch, F., Coleman, K. J., … Carrell, D. S. (2018). Care pathways before first diagnosis of a psychotic disorder in adolescents and young adults. The American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2017.17080844.

  58. New York City Department of Health and Mental Hygiene. (n.d.). New York City Supportive Transition and Recovery Team (NYC START). https://www1.nyc.gov/site/doh/health/health-topics/crisis-emergency-services-nyc-start.page. Accessed November 23, 2017.

  59. Simon, G. E., Coleman, K. J., Yarborough, B. J. H., Operskalski, B., Stewart, C., Hunkeler, E. M., … Beck, A. (2017). First presentation with psychotic symptoms in a population-based sample. Psychiatric Services, 68, 456–461. https://doi.org/10.1176/appi.ps.201600257.

  60. Ford, E. (2015). First-episode psychosis in the criminal justice system: Identifying a critical intercept for early intervention. Harvard Review of Psychiatry, 23, 167–175. https://doi.org/10.1097/HRP.0000000000000066.

    Article  Google Scholar 

  61. Donabedian, A. (1988). The quality of care: How can it be assessed? Journal American Medical Association, 260, 1743–1748. https://doi.org/10.1001/jama.1988.03410120089033.

    Article  Google Scholar 

  62. Elbogen, E. B., Van Dorn, R. A., Swanson, J. W., Swartz, M. S., & Monahan, J. (2006). Treatment engagement and violence risk in mental disorders. British Journal of Psychiatry, 189, 354–360. https://doi.org/10.1192/bjp.bp.105.017913.

    Article  Google Scholar 

  63. Fazel, S., Zetterqvist, J., Larsson, H., Langstrom, N., & Lichtenstein, P. (2014). Antipsychotics, mood stabilisers, and risk of violent crime. The Lancet, 384, 1206–1214. https://doi.org/10.1016/S0140-6736(14)60379-2.

    Article  Google Scholar 

  64. Smith, T., Myers, R., Sederer, L., & Berezin, J. (2016). How value-based payment arrangements should measure behavioral health. Health Affairs Blog. https://doi.org/10.1377/hblog20161129.057660.

  65. PhenX Toolkit, Version 22.1. (2018, January 18). Early Psychosis Translational Research Specialty Collection. https://www.phenxtoolkit.org/index.php?pageLink=browse.nimh.eptr. Accessed February 19, 2018.

  66. Burstin, H., Leatherman, S., & Goldmann, D. (2016). The evolution of healthcare quality measurement in the United States. Journal of Internal Medicine, 279, 154–159. https://doi.org/10.1111/joim.12471.

    Article  Google Scholar 

  67. Radhakrishnan, M., McCrone, P., Lafortune, L., Everard, L., Fowler, D., Amos, T., … Birchwood, M. (2017). Cost-effectiveness of early intervention services for psychosis and fidelity to national policy implementation guidance. Early Intervention in Psychiatry, 1–10. https://doi.org/10.1111/eip.12481.

  68. Bennett, M., Piscitelli, S., Goldman, H., Essock, S., & Dixon, L. (2014). Coordinated specialty care for first episode psychosis—Manual II: Implementation. Rockville, MD: National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/schizophrenia/raise/csc-for-fep-manual-ii-implementation-manual_147093.pdf. Accessed November 23, 2017.

  69. Centers for Medicare & Medicaid Services (CMS). (n.d). Medicaid.gov: Authorities for home and community based services. https://www.medicaid.gov/medicaid/hcbs/authorities/index.html. Accessed November 24, 2017.

  70. Musumeci, M. (2017, November). Issue brief: Key themes in Medicaid Section 1115 behavioral health waivers. Menlo Park, CA: The Henry J. Kaiser Family Foundation. http://files.kff.org/attachment/Issue-Brief-Key-Themes-in-Medicaid-Section-1115-Behavioral-Health-Waivers. Accessed March 12, 2018.

  71. Centers for Medicare & Medicaid Services (CMS). (2016). Medicaid and Children’s Health Insurance Program (CHIP) programs; Medicaid managed care, CHIP delivered in managed care, and revisions related to third party liability. Federal Register, 81, 27497–27901. https://www.federalregister.gov/documents/2016/05/06/2016-09581/medicaid-and-childrens-health-insurance-program-chip-programs-medicaid-managed-care-chip-delivered. Accessed November 24, 2017.

  72. Frank, R. G., Glied, S. A., & McGuire, T. G. (2015). Paying for early interventions in psychoses: A three-part model. Psychiatric Services, 66, 677–679. https://doi.org/10.1176/appi.ps.201400076.

    Article  Google Scholar 

  73. Humensky, J. L., Dixon, L. B., & Essock, S. M. (2013). State mental health policy: An interactive tool to estimate costs and resources for a first-episode psychosis initiative in New York State. Psychiatric Services, 64, 832–834. https://doi.org/10.1176/appi.ps.201300186.

    Article  Google Scholar 

  74. Essock, S. M., Goldman, H. H., Hogan, M. F., Hepburn, B. M., Sederer, L. I., & Dixon, L. B. (2015). State partnerships for first-episode psychosis services. Psychiatric Services, 66, 671–673. https://doi.org/10.1176/appi.ps.201400117.

    Article  Google Scholar 

  75. Bello, I., Lee, R., Malinovsky, I., Watkins, L., Nossel, I., Smith, T., … Dixon, L. B. (2017). OnTrackNY: The development of a coordinated specialty care program for individuals experiencing early psychosis. Psychiatric Services, 68, 318–320. https://doi.org/10.1176/appi.ps.201600512.

  76. Wachino, V., Insel, T., & Enomoto, K. (2015, October 16). Coverage of early intervention services for first episode psychosis. Centers for Medicare & Medicaid Services (CMS). https://www.medicaid.gov/federal-policy-guidance/downloads/cib-10-16-2015.pdf. Accessed November 24, 2017.

  77. Goldman, H. H., Karakus, M., Frey, W., & Beronio, K. (2013). Economic grand rounds: Financing first-episode psychosis services in the United States. Psychiatric Services, 64, 506–508. https://doi.org/10.1176/appi.ps.201300106.

    Article  Google Scholar 

  78. Srihari, V. H., Tek, C., Pollard, J., Zimmet, S., Keat, J., Cahill, J. D., … Woods, S. W. (2014). Reducing the duration of untreated psychosis and its impact in the US: The STEP-ED study. BioMed Center Psychiatry, 14, 335. https://doi.org/10.1186/s12888-014-0335-3.

  79. Heinssen, R. K. (2018, January 25). NAMHC concept clearance: Research to inform stepped-care interventions for persons at clinical high risk for psychosis. National Institute of Mental Health. https://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2018/research-to-inform-stepped-care-interventions-for-persons-at-clinical-high-risk-for-psychosis.shtml. Accessed February 19, 2018.

  80. van der Gaag, M., Smit, F., Bechdolf, A., French, P., Linszen, D. H., Yung, A. R., … Cuijpers, P. (2013). Preventing a first episode of psychosis: Meta-analysis of randomized controlled prevention trials of 12 month and longer-term follow-ups. Schizophrenia Research, 149, 56–62. https://doi.org/10.1016/j.schres.2013.07.004.

  81. van der Gaag, M., van den Berg, D., & Ising, H. (2017). CBT in the prevention of psychosis and other severe mental disorders in patients with an at risk mental state: A review and proposed next steps. Schizophrenia Research, 1–6. https://doi.org/10.1016/j.schres.2017.08.018.

  82. Morrison, A. P., Law, H., Carter, L., Sellers, R., Emsley, R., Pyle, M., … Haddad, P. M. (2018). Antipsychotic drugs versus cognitive behavioural therapy versus a combination of both in people with psychosis: A randomised controlled pilot and feasibility study. Lancet Psychiatry, 5, 411–423. https://doi.org/10.1016/s2215-0366(18)30096-8.

  83. Valmaggia, L. R., Byrne, M., Day, F., Broome, M. R., Johns, L., Howes, O., … McGuire, P. K. (2015). Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase. The British Journal of Psychiatry, 207, 130–134. https://doi.org/10.1192/bjp.bp.114.150623.

  84. McFarlane, W. R., Cook, W. L., Downing, D., Ruff, A., Lynch, S., Adelsheim, S., … Milner, K. (2012). Early detection, intervention, and prevention of psychosis program: Rationale, design, and sample description. Adolescent Psychiatry, 2, 112–124.

    Google Scholar 

  85. McFarlane, W. R., Levin, B., Travis, L., Lucas, F. L., Lynch, S., Verdi, M., … Spring, E. (2015). Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial. Schizophrenia Bulletin, 41, 30–43. https://doi.org/10.1093/schbul/sbu108.

  86. Carrión, R. E., Cornblatt, B. A., Burton, C. Z., Tso, I. F., Auther, A. M., Adelsheim, S., … McFarlane, W. R. (2016). Personalized prediction of psychosis: External validation of the NAPLS-2 psychosis risk calculator with the EDIPPP project. The American Journal of Psychiatry, 173, 989–996. https://doi.org/10.1176/appi.ajp.2016.15121565.

  87. Fusar-Poli, P., Cappucciati, M., Borgwardt, S., Woods, S. W., Addington, J., Nelson, B., … McGuire, P. K. (2016). Heterogeneity of psychosis risk within individuals at clinical high risk: A meta-analytical stratification. Journal American Medical Association Psychiatry, 73, 113–120. https://doi.org/10.1001/jamapsychiatry.2015.2324.

  88. Goldman, H. H. (2018). Early intervention: What it means and what it implies. Psychiatric Services, 69(8), 841. https://doi.org/10.1176/appi.ps.69802.

    Article  Google Scholar 

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Smith, T.E., Dixon, L.B. (2020). Early Intervention in Psychosis: From Science to Services. In: Goldman, H., Frank, R., Morrissey, J. (eds) The Palgrave Handbook of American Mental Health Policy. Palgrave Macmillan, Cham. https://doi.org/10.1007/978-3-030-11908-9_11

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