Lymphoid Follicles: Reactive vs. Neoplastic

  • Antonio Subtil


Lymphoid follicles are not native to the skin, and their presence in the dermis is a pathologic finding. They can be reactive (benign) or neoplastic (malignant) and can be present in several types of pseudolymphoma and in low-grade cutaneous B-cell lymphomas. The distinguishing histomorphologic features include their distribution, mantle zone preservation, mitotic activity, tingible body macrophages, and polarization.


Lymphoid Follicles Reactive Neoplastic Germinal center Histopathology 

Suggested Readings

  1. Leinweber B, Colli C, Chott A, Kerl H, Cerroni L. Differential diagnosis of cutaneous infiltrates of B lymphocytes with follicular growth pattern. Am J Dermatopathol. 2004;26(1):4–13.CrossRefGoogle Scholar
  2. Subtil A. A general approach to the diagnosis of cutaneous lymphomas and pseudolymphomas. Cutaneous lymphomas (Subtil, ed.). Surg Pathol Clin. 2014;7(2):135–42. Elsevier: Philadelphia.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Antonio Subtil
    • 1
  1. 1.Dermatology and PathologyYale UniversityNew HavenUSA

Personalised recommendations