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Skin

  • Maria Cristina Isales
  • Timothy Tan
  • Lily MarsdenEmail author

Abstract

In both the fetus and adult, the skin is the largest organ of the body. During fetal life, the skin undergoes a complex expansion to form a multilayered structure that can re-epithelialize after injury, prevent dehydration, and protect against infection. Not surprisingly, fetal and adult skin differ greatly both in structure and in epidermal and dermal protein component expression. Though not well understood, these unique expression profiles, especially in extracellular matrix molecules, impart fetal skin with the ability to rapidly re-epithelialize and restore normal skin architecture without scar formation. By late gestation, this scarless wound healing has ceased, and protein expression and the cellular composition of the skin layers have evolved into those recognized in adults. This chapter highlights the structural evolution and histological changes that occur in the skin during fetal life.

Keywords

Epidermal Dermis Hypodermis Ectoderm Mesoderm Periderm Hair Sebaceous glands Eccrine glands Apocrine glands Nails 

References

  1. 1.
    McGrath JA, Eady RAJ, Pope FM. Anatomy and organization of human skin. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s textbook of dermatology. 7th ed. Malden: Blackwell Publishing; 2004.Google Scholar
  2. 2.
    Helmo FR, Machado JR, Oliveira LF, Rocha LP, Cavellani CL, Teixeira Vde P, et al. Morphological and inflammatory changes in the skin of autopsied fetuses according to the type of stress. Pathol Res Pract. 2015;211:858–64.CrossRefGoogle Scholar
  3. 3.
    Fuchs E. Scratching the surface of skin development. Nature. 2007;445:834–42.CrossRefGoogle Scholar
  4. 4.
    Koster MI, Loomis CA, Koss T, Chu D. Skin development and maintenance. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. Philadelphia: Elsevier Saunders; 2018. p. 56–65.Google Scholar
  5. 5.
    Kim DK, Holbrook KA. The appearance, density, and distribution of Merkel cells in human embryonic and fetal skin: their relation to sweat gland and hair follicle development. J Invest Dermatol. 1995;104:411–6.CrossRefGoogle Scholar
  6. 6.
    Van Keymeulen A, Mascre G, Youseff KK, Harel I, Michaux C, De Geest N, et al. Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol. 2009;187:91–100.CrossRefGoogle Scholar
  7. 7.
    Foster CA, Holbrook KA, Farr AG. Ontogeny of Langerhans cells in human embryonic and fetal skin: expression of HLA-DR and OKT-6 determinants. J Invest Dermatol. 1986;86:240–3.CrossRefGoogle Scholar
  8. 8.
    Schoenwolf GC, Bleyl SB, Brauer PR, Francis-West PH. Development of the skin and its derivatives. In:Larsen’s human embryology. 5th ed. Philadelphia: Elsevier/Churchill Livingstone; 2015. p. 155–71.Google Scholar
  9. 9.
    Ersch J, Stallmach T. Assessing gestational age from histology of fetal skin: an autopsy study of 379 fetuses. Obstet Gynecol. 1999;94:753–7.PubMedGoogle Scholar
  10. 10.
    Hoath SB, Mauro T. Fetal skin development. In: Eichenfeld LF, Frieden IJ, editors. Neonatal and infant dermatology. London: Elsevier Saunders; 2015. p. 1–13.Google Scholar
  11. 11.
    Smith LT, Holbrook KA. Embryogenesis of the dermis in human skin. Pediatr Dermatol. 1986;3:271–80.CrossRefGoogle Scholar
  12. 12.
    Johnson CL, Holbrook KA. Development of human embryonic and fetal dermal vasculature. J Invest Dermatol. 1989;93:10S–7S.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Maria Cristina Isales
    • 1
  • Timothy Tan
    • 1
  • Lily Marsden
    • 2
    Email author
  1. 1.Department of PathologyNorthwestern Memorial Hospital, Northwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Utah State Office of the Medical ExaminerSalt Lake CityUSA

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