In the developing embryo and fetus, hematopoiesis is a dynamic process that starts in the yolk sac, continues in the liver, and finally stabilizes in the bone marrow. Starting at 11 weeks gestation, hematopoiesis begins in the bone marrow and will remain there throughout adult life. Hematopoiesis begins with self-renewing multipotent stem cells that give rise to committed progenitor cells, which ultimately differentiate into the cells that circulate in the peripheral blood. This chapter reviews the structure of the normal fetal bone marrow and discusses specific aspects of myelopoiesis, erythropoiesis, lymphopoiesis, and megakaryopoiesis.
KeywordsHematopoiesis Hemangioblast Yolk sac Embryonic hemoglobins Myelopoiesis Lymphopoiesis Hematogones Hemophagocytosis
- 1.Foucar K. Bone marrow pathology. 2nd ed. Chicago: American Society for Clinical Pathology Press; 2001.Google Scholar
- 5.Wickramasinghe SN. Bone marrow. In: Mills SE, editor. Histology for pathologists. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 799–836.Google Scholar
- 8.Foucar K, Viswanatha DS, Wilson CS. Non-neoplastic disorders of bone marrow. In:Atlas of nontumor pathology. Washington, DC: American Registry of Pathology Press; 2009.Google Scholar