Adrenal Androgens Impact on Neurosteroids
The steroidogenic endocrine glands and local synthesis both contribute to the pool of steroids present in the central nervous system and peripheral nervous system. The available clinical and experimental findings support the critical role of neurosteroids during fertile life and reproductive aging and their relationship with endogenous and exogenous sex steroids. Protective steroid hormones such as dehydroepiandrosterone (DHEA) and particularly its sulfated derivative, DHEA sulfate (DHEAS), are the most abundant circulating steroid hormones; but the plasma concentrations of DHEA and DHEAS progressively decline with age. Evidence suggests that lower levels of DHEA are associated with cardiovascular, cognitive, and sexual impairment in women. The brain metabolism and the implications of DHEA treatment in postmenopausal women will also be discussed.
KeywordsAndrogens Neurosteroids DHEA Adrenal Brain CNS
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