A Perspective on Comparative and Functional Genomics
Comparing genomes based on the order of genes provides insights into their evolutionary history and further allows to identify sets of genes with associated function. In the past two decades, many methods have been developed for identifying genomic regions that share homologous genes, which can be subsequently tested for functional associativity. As these methods are flexible by tolerating duplicate, missing, and intruding genes, we now study a case in which relationships between genes are established through a hierarchical relationship and thereby turn the problem of identifying regions with common functional associations inside out: We use a measure of dissimilarity between genes defined on a gene ontology hierarchy to identify collections of genomic regions with low functional dissimilarity.
KeywordsGene order comparison Functional genomics Functional dissimilarity
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