Abstract
Colorectal cancer is the third most common cancer and the fourth most common cancer cause of death globally, accounting for roughly 1.2 million new cases and 600,000 deaths per year [1]. Incidence is low at ages younger than 50 years, but strongly increases with age. Median age at diagnosis is about 70 years in developed countries [2]. Colorectal cancer develops mostly without any symptoms in the early stages. In 15–30% of cases, however, CRC patients present with symptoms of acute abdomen such as bowel perforation, obstruction, or gastrointestinal bleeding [3]. Those complications mostly occur in elderly patients and are associated with poor prognosis [4]. These poor outcomes start at their initial hospital admission and also impacts long-term survival [3]. Elderly patients with CRC may be specifically at risk for emergent presentation because of medical comorbid conditions, insufficient screening, unrecognized symptoms, and inadequate overall access to the health-care system [4]. Imaging hence plays a key role in this setting. Its first objective is to provide the earliest diagnosis of any complication. Its second objective is increasingly dealing with interventional therapy of some complications associated with colorectal cancer treatment. This chapter will go through the role of imaging in the four major complications occurring in colorectal cancer setting, with a special focus on the pre-therapeutic imaging strategy in complicated or advanced CRC.
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References
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.
Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62(4):220–41.
Wong SKC, Jalaludin BB, Morgan MJ, Berthelsen AS, Morgan A, Gatenby AH, et al. Tumor pathology and long-term survival in emergency colorectal cancer. Dis Colon Rectum. 2008;51(2):223–30.
McGillicuddy EA, Schuster KM, Davis KA, Longo WE. Factors predicting morbidity and mortality in emergency colorectal procedures in elderly patients. Arch Surg. 2009;144(12):1157–62.
Biondo S, Kreisler E, Millan M, Fraccalvieri D, Golda T, Martí Ragué J, et al. Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer. Am J Surg. 2008;195(4):427–32.
Horton KM, Abrams RA, Fishman EK. Spiral CT of colon cancer: imaging features and role in management. Radiographics. 2000;20(2):419–30.
Taourel P, Kessler N, Lesnik A, Pujol J, Morcos L, Bruel JM. Helical CT of large bowel obstruction. Abdom Imaging. 2003;28(2):267–75.
Sabbagh C, Siembida N, Yzet T, Robert B, Chivot C, Browet F, et al. What are the predictive factors of caecal perforation in patients with obstructing distal colon cancer? Colorectal Dis. 2018;20:688.
Carraro PG, Segala M, Cesana BM, Tiberio G. Obstructing colonic cancer: failure and survival patterns over a ten-year follow-up after one-stage curative surgery. Dis Colon Rectum. 2001;44(2):243–50.
Zhang Y, Shi J, Shi B, Song C-Y, Xie W-F, Chen Y-X. Self-expanding metallic stent as a bridge to surgery versus emergency surgery for obstructive colorectal cancer: a meta-analysis. Surg Endosc. 2012;26(1):110–9.
Kim SW, Kim HC, Yang DM. Perforated tumours in the gastrointestinal tract: CT findings and clinical implications. Br J Radiol. 2012;85(1017):1307–13.
Abdelrazeq AS, Scott N, Thorn C, Verbeke CS, Ambrose NS, Botterill ID, et al. The impact of spontaneous tumour perforation on outcome following colon cancer surgery. Colorectal Dis. 2008;10(8):775–80.
Badía JM, Sitges-Serra A, Pla J, Ragué JM, Roqueta F, Sitges-Creus A. Perforation of colonic neoplasms. A review of 36 cases. Int J Colorectal Dis. 1987;2(4):187–9.
Biondo S, Martí-Ragué J, Kreisler E, Parés D, Martín A, Navarro M, et al. A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg. 2005;189(4):377–83.
Catalano O. [Perforated carcinoma of the colorectum. Computerized tomography findings]. Radiol Med 1997;93(1–2):83–86.
Cheynel N, Cortet M, Lepage C, Ortega-Debalon P, Faivre J, Bouvier A-M. Incidence, patterns of failure, and prognosis of perforated colorectal cancers in a well-defined population. Dis Colon Rectum. 2009;52(3):406–11.
Kim SW, Shin HC, Kim IY, Kim YT, Kim C-J. CT findings of colonic complications associated with colon cancer. Korean J Radiol. 2010;11(2):211–21.
Udayasankar UK, Li J, Baumgarten DA, Small WC, Kalra MK. Acute abdominal pain: value of non-contrast enhanced ultra-low-dose multi-detector row CT as a substitute for abdominal radiographs. Emerg Radiol. 2009;16(1):61–70.
Tsai H-L, Hsieh J-S, Yu F-J, Wu D-C, Chen F-M, Huang C-J, et al. Perforated colonic cancer presenting as intra-abdominal abscess. Int J Colorectal Dis. 2007;22(1):15–9.
Goh V, Halligan S, Taylor SA, Burling D, Bassett P, Bartram CI. Differentiation between diverticulitis and colorectal cancer: quantitative CT perfusion measurements versus morphologic criteria--initial experience. Radiology. 2007;242(2):456–62.
Pereira JM, Sirlin CB, Pinto PS, Jeffrey RB, Stella DL, Casola G. Disproportionate fat stranding: a helpful CT sign in patients with acute abdominal pain. Radiographics. 2004;24(3):703–15.
Fernandes T, Oliveira MI, Castro R, Araújo B, Viamonte B, Cunha R. Bowel wall thickening at CT: simplifying the diagnosis. Insights Imaging. 2014;5(2):195–208.
Chintapalli KN, Esola CC, Chopra S, Ghiatas AA, Dodd GD. Pericolic mesenteric lymph nodes: an aid in distinguishing diverticulitis from cancer of the colon. AJR Am J Roentgenol. 1997;169(5):1253–5.
Shen S-H, Chen J-D, Tiu C-M, Chou Y-H, Chiang J-H, Chang C-Y, et al. Differentiating colonic diverticulitis from colon cancer: the value of computed tomography in the emergency setting. J Chin Med Assoc. 2005;68(9):411–8.
Lecleire S, Nahon S, Alatawi A, Antonietti M, Chaput U, Di-Fiore A, et al. Diagnostic impact of routine colonoscopy following acute diverticulitis: a multicenter study in 808 patients and controls. United Eur Gastroenterol J. 2014;2(4):301–6.
Strate LL, Naumann CR. The role of colonoscopy and radiological procedures in the management of acute lower intestinal bleeding. Clin Gastroenterol Hepatol. 2010;8(4):333–43. quiz e44.
ASGE Standards of Practice Committee, Pasha SF, Shergill A, Acosta RD, Chandrasekhara V, Chathadi KV, et al. The role of endoscopy in the patient with lower GI bleeding. Gastrointest Endosc. 2014;79(6):875–85.
Geffroy Y, Rodallec MH, Boulay-Coletta I, Jullès M-C, Fullès M-C, Ridereau-Zins C, et al. Multidetector CT angiography in acute gastrointestinal bleeding: why, when, and how. Radiographics. 2011;31(3):E35–46.
Valek V, Husty J. Quality improvement guidelines for transcatheter embolization for acute gastrointestinal nonvariceal hemorrhage. Cardiovasc Intervent Radiol. 2013;36(3):608–12.
Jaeckle T, Stuber G, Hoffmann MHK, Jeltsch M, Schmitz BL, Aschoff AJ. Detection and localization of acute upper and lower gastrointestinal (GI) bleeding with arterial phase multi-detector row helical CT. Eur Radiol. 2008;18(7):1406–13.
Ernst O, Bulois P, Saint-Drenant S, Leroy C, Paris J-C, Sergent G. Helical CT in acute lower gastrointestinal bleeding. Eur Radiol. 2003;13(1):114–7.
Zahid A, Young CJ. Making decisions using radiology in lower GI hemorrhage. Int J Surg. 2016;31:100–3.
Tew K, Davies RP, Jadun CK, Kew J. MDCT of acute lower gastrointestinal bleeding. AJR Am J Roentgenol. 2004;182(2):427–30.
Kuhle WG, Sheiman RG. Detection of active colonic hemorrhage with use of helical CT: findings in a swine model. Radiology. 2003;228(3):743–52.
Dobritz M, Engels H-P, Schneider A, Wieder H, Feussner H, Rummeny EJ, et al. Evaluation of dual-phase multi-detector-row CT for detection of intestinal bleeding using an experimental bowel model. Eur Radiol. 2009;19(4):875–81.
Chan V, Tse D, Dixon S, Shrivastava V, Bratby M, Anthony S, et al. Outcome following a negative CT Angiogram for gastrointestinal hemorrhage. Cardiovasc Intervent Radiol. 2015;38(2):329–35.
Evangelista PT, Hallisey MJ. Transcatheter embolization for acute lower gastrointestinal hemorrhage. J Vasc Interv Radiol. 2000;11(5):601–6.
McArdle CS, Hole DJ. Emergency presentation of colorectal cancer is associated with poor 5-year survival. Br J Surg. 2004;91(5):605–9.
Expert Panel on Gastrointestinal Imaging, Fowler KJ, Kaur H, Cash BD, Feig BW, Gage KL, et al. ACR Appropriateness Criteria® pretreatment staging of colorectal cancer. J Am Coll Radiol. 2017;14(5S):S234–44.
Floriani I, Torri V, Rulli E, Garavaglia D, Compagnoni A, Salvolini L, et al. Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging. 2010;31(1):19–31.
Polat E, Bostanci EB, Aksoy E, Karaman K, Poyraz NY, Duman U, et al. The impact of PET/CT on the management of hepatic and extra hepatic metastases from gastrointestinal cancers. Eur J Radiol. 2015;84(6):1165–70.
Truant S, Huglo D, Hebbar M, Ernst O, Steinling M, Pruvot F-R. Prospective evaluation of the impact of [18F]fluoro-2-deoxy-D-glucose positron emission tomography of resectable colorectal liver metastases. Br J Surg. 2005;92(3):362–9.
Halligan S, Altman DG, Taylor SA, Mallett S, Deeks JJ, Bartram CI, et al. CT colonography in the detection of colorectal polyps and cancer: systematic review, meta-analysis, and proposed minimum data set for study level reporting. Radiology. 2005;237(3):893–904.
Flor N, Ceretti AP, Mezzanzanica M, Rigamonti P, Peri M, Tresoldi S, et al. Impact of contrast-enhanced computed tomography colonography on laparoscopic surgical planning of colorectal cancer. Abdom Imaging. 2013;38(5):1024–32.
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Galletto, A. et al. (2019). Complicated Colorectal Cancer: Role of Imaging. In: de'Angelis, N., Di Saverio, S., Brunetti, F. (eds) Emergency Surgical Management of Colorectal Cancer. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-030-06225-5_5
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DOI: https://doi.org/10.1007/978-3-030-06225-5_5
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