Surface Modification and Bioconjugation of Nanoparticles for MRI Technology

  • M. Azam AliEmail author
  • Mohammad Tajul Islam


Nanomaterials (NPs) with precise biological functions have considerable potential for use in biomedical applications. Surface modification is one of the effective routes to impart such desired and precise biological functions to NPs. Introduction of various reactive functional groups on the surface of NPs are required to conjugate a spectrum of contrast agents (CAs), for the targeted imaging such as magnetic resonance imaging (MRI). Current state in surface modification of NPs for preparing CAs of MRI is summarized in this chapter. Chemistries involved in the bioconjugation and surface modification are discussed. Chemical and bioconjugate reactions to transform the surface of NPs such as silica NPs, gold NPs, and gadolinium NPs are highlighted. Coating is another important approach to enhance the functionalities of CAs for MRI application, therefore, light is thrown on the coating mechanism of organic polymers including dextran, chitosan, and copolymers.


Surface modification Bioconjugation Nanoparticles Contrast agent Magnetic resonance image 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Centre for Bioengineering and Nanomedicine, Department of Food Science, Division of SciencesUniversity of OtagoDunedinNew Zealand
  2. 2.Centre for Materials Science and TechnologyUniversity of OtagoDunedinNew Zealand

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