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Applications of Ion-Exchange Chromatography in Pharmaceutical Analysis

  • Sayed M. Derayea
  • Hytham M. AhmedEmail author
Chapter

Abstract

Ion-exchange chromatography represents a versatile way for the separation of highly polar (acidic and basic) compounds including pharmaceuticals, whereas the use of reversed-phase chromatography is not feasible. Symmetrical peaks with suitable retention times and exclusive selectivity were achieved using such technique. Compounds with strong UV absorption could be easily analyzed. However, for the analysis of substances lacking UV absorbance, several approaches have been followed to overcome the problem of using buffer salts (such as phosphate) which prevent the use of universal detectors. One of these approaches was the use of indirect UV detection. Alternatively, the mixed-mode column has been used in which volatile buffer solutions were applied; therefore, universal detectors can be applied. In addition to quantitative analysis, ion-exchange chromatography has been widely applied for sample purification or preconcentration steps prior to analysis.

List of Abbreviations

DAD

Diode array detector

ESI

Electrospray ionization

HILIC

Hydrophilic interaction liquid chromatography

MAX

Mixed anion exchange

MCX

Mixed cation exchange

MS

Mass spectrometry

ODS

Octadecylsilane

PBD-ZrO2

Polybutadiene-coated zirconia

PGRP

Positively charged reversed phase

RPLC

Reversed-phase liquid chromatography

SAX

Strong anion exchange

SCX

Strong cation exchange

SPE

Solid-phase extraction

UV

Ultraviolet

WCX

Weak cation exchange

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Authors and Affiliations

  1. 1.Analytical Chemistry Department, Faculty of PharmacyMinia UniversityMiniaEgypt
  2. 2.Pharmaceutical Analysis Department, Faculty of PharmacyMenoufia UniversityShibin El KomEgypt

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