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Acid-Base Disorders and Regional Citrate Anticoagulation with Continuous Renal Replacement Therapy

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Annual Update in Intensive Care and Emergency Medicine 2019

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

Abstract

Citrate delivery with continuous renal replacement therapy (CRRT) enables provision of real regional anticoagulation. Several meta-analyses have strongly confirmed that regional citrate anticoagulation (RCA) is more efficient (longer circuit lifespan) and safer (lower bleeding risk) than heparin [1–3]. Besides these beneficial effects, three recent high-quality randomized controlled trials (RCTs) have demonstrated that metabolic complications are now uncommon, transient and easily preventable when RCA is implemented using a formalized strategy [4–6]. Therefore, RCA is now recommended as the first choice for anticoagulation during CRRT [7, 8].

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Authors and Affiliations

  1. Polyvalent Intensive Care Unit, Hôpital Pasteur 2, University Hospital of Nice, University Côte D’Azur, Nice, France

    C. Ichai & H. Quintard

  2. UMR 7275 CNRS, Valbonne, France

    H. Quintard

  3. Department of Anesthesiology and Critical Care Medicine, Institut de Neuroscience de la Timone (INT), University Hospital La Timone, Aix Marseille University, Marseille, France

    L. Velly

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  1. C. Ichai
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  2. H. Quintard
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  3. L. Velly
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Correspondence to C. Ichai .

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Editors and Affiliations

  1. Dept. of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent

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Ichai, C., Quintard, H., Velly, L. (2019). Acid-Base Disorders and Regional Citrate Anticoagulation with Continuous Renal Replacement Therapy. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2019. Annual Update in Intensive Care and Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-06067-1_30

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  • DOI: https://doi.org/10.1007/978-3-030-06067-1_30

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  • Online ISBN: 978-3-030-06067-1

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