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Basal Cell Carcinoma

  • Mordechai Rosner
  • Ido Didi Fabian
Chapter

Abstract

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the periocular area. While the mortality from BCC is low, it is capable of extensive tissue destruction, and the morbidity may be considerable. The main risk factor is ultraviolet irradiation. The most important diagnostic evaluation is histopathologic examination of the excised tissue. The main treatment modality for BCC is surgical excision of the lesion with microscopic monitoring of its margins or Mohs’ microsurgery. Long-term clinical follow-up after treatment is necessary.

Keywords

Basal cell carcinoma Skin Eyelid Periocular Tumor Malignancy Ultraviolet Immune dysfunction Ionizing radiation Trauma Gorlin–Goltz syndrome Xeroderma pigmentosum Albinism Basex–Dupré syndrome Muir–Torre syndrome Rombo syndrome Linear basocellular hamartoma Sebaceous hamartoma of Jadassohn Histopathology Epidermis Basal cell Palisading Gap Surgery Mohs’ microsurgery Curettage Electrodessication Cryosurgery Radiotherapy Chemotherapy Photodynamic therapy Immunotherapy α-Interferon Imiquimod Vismodegib Hedgehog signaling pathway 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mordechai Rosner
    • 1
  • Ido Didi Fabian
    • 2
  1. 1.Department of Ophthalmology, Eye Histopathology LaboratoryGoldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv UniversityTel AvivIsrael
  2. 2.Department of OphthalmologyOcular Oncology Center, Goldschleger Eye Institute, Sheba Medical Center, Sackler School of Medicine, Tel Aviv UniversityTel AvivIsrael

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