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Medtronic Program for Transcatheter Aortic Valve Implantation

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Transcatheter Aortic Valve Implantation

Abstract

Medtronic CoreValve (Medtronic, Inc., Minneapolis, Minnesota) is the first self-expandable transcatheter heart valve introduced to the market, characterized by supra-annular design to enhance valve function, after obtaining Conformité Européenne (CE) Mark in 2007. CoreValve has undergone design changes to improve function to reduce transcatheter aortic valve implantation (TAVI)-related complications such as vascular complications, paravalvular leak, and pacemaker implantation. CoreValve Evolut R, a smaller profile delivery system, provides an option for valve recapture and repositioning that can assist in the precise deployment of the valve. The most recent commercially available CoreValve Evolut PRO is equipped with an outer wrap designed to enhance the contact between the valve and the aortic annulus. Many studies have shown efficacy of these devices on various patients with different comorbidities and surgical risks including extreme, high, intermediate, or even low risk. Medtronic, Inc. devices are the most commonly used self-expandable transcatheter heart valves for patients who have severe aortic stenosis and undergo TAVI and have been implanted in more than 160,000 patients worldwide (until October 2017). Ongoing trials are expected to obtain TAVI indication for younger and lower surgical-risk patients, while there still remain issues to improve outcomes and long-term safety.

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Acknowledgments

Armando Vergara-Martel: The Valve and Structural Heart Disease Intervention Center, Division of Cardiovascular Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center.

COI Disclosure

Dr. Patel reports honoraria and personal fees from Abbott Vascular, Boston Scientific, and Medtronic. Dr. Kalra reports personal fees from Medtronic and Philips. Dr. Attizzani is a consultant and proctor for Edwards Lifesciences and Medtronic; consultant for Abbott Vascular. The remaining authors report no conflicts of interest.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, The Valve & Structural Heart Disease Intervention Center, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA

    Yasuhiro Ichibori, Sandeep M. Patel, Ankur Kalra & Guilherme F. Attizzani

  2. Structural Heart Center, St. Rita’s Medical Center (Mercy), Lima, OH, USA

    Sandeep M. Patel

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  1. Yasuhiro Ichibori
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Correspondence to Guilherme F. Attizzani .

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  1. Interventional Cardiology Unit, Pineta Grande Hospital, Castel Volturno, Caserta, Italy

    Arturo Giordano

  2. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy

    Giuseppe Biondi-Zoccai  & Giacomo Frati  & 

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Ichibori, Y., Patel, S.M., Kalra, A., Attizzani, G.F. (2019). Medtronic Program for Transcatheter Aortic Valve Implantation. In: Giordano, A., Biondi-Zoccai, G., Frati, G. (eds) Transcatheter Aortic Valve Implantation. Springer, Cham. https://doi.org/10.1007/978-3-030-05912-5_24

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