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Augmenting Embedding with Domain Knowledge for Oral Disease Diagnosis Prediction

  • Guangkai Li
  • Songmao Zhang
  • Jie Liang
  • Zhanqiang Cao
  • Chuanbin Guo
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11344)

Abstract

In this paper, we propose to add domain knowledge from the most comprehensive biomedical ontology SNOMED CT to facilitate the embedding of EMR symptoms and diagnoses for oral disease prediction. We first learn embeddings of SNOMED CT concepts by applying the TransE algorithm prevalent for representation learning of knowledge base. Secondly, the mapping from symptoms/diagnoses to biomedical concepts and the corresponding semantic relations defined in SNOMED CT are modeled mathematically. We design a neural network to train embeddings of EMR symptoms and diagnoses and ontological concepts in a coherent way, for the latter the TransE-learned vectors being used as initial values. The evaluation on real-world EMR datasets from Peking University School and Hospital Stomatology demonstrates the prediction performance improvement over embeddings solely based on EMRs. This study contributes as a first attempt to learn distributed representations of EMR symptoms and diagnoses under the constraint of embeddings of biomedical concepts from comprehensive clinical ontology. Incorporating domain knowledge can augment embedding as it reveals intrinsic correlation among symptoms and diagnoses that cannot be discovered by EMR data alone.

Keywords

Biomedical ontology Embedding Diagnosis prediction EMR data 

Notes

Acknowledgements

This work has been supported by the National Key Research and Development Program of China under grant 2016YFB1000902, Projects of Beijing Municipal Science & Technology Commission, and the Natural Science Foundation of China grant 61621003.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Guangkai Li
    • 1
  • Songmao Zhang
    • 1
  • Jie Liang
    • 2
  • Zhanqiang Cao
    • 3
  • Chuanbin Guo
    • 2
  1. 1.MADIS, Academy of Mathematics and Systems Science, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesBeijingChina
  2. 2.Department of Oral and Maxillofacial SurgeryPeking University School and Hospital of StomatologyBeijingChina
  3. 3.Information CenterPeking University School and Hospital of StomatologyBeijingChina

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