Neuroimaging Studies of Cognitive Function in Schizophrenia

  • Rafael PenadésEmail author
  • Nicolas Franck
  • Laura González-Vallespí
  • Marie Dekerle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1118)


Persons suffering from schizophrenia present cognitive impairments that have a major functional impact on their lives. Particularly, executive functions and episodic memory are consistently found to be impaired. Neuroimaging allows the investigation of affected areas of the brain associated with these impairments and, moreover, the detection of brain functioning improvements after cognitive remediation interventions. For instance, executive function impairments have been associated with prefrontal cortex volume and thickness; cognitive control impairments are correlated with an increased activation in the anterior cingulate cortex, and episodic memory impairments are linked to hippocampal reduction. Some findings suggest the presence of brain compensatory mechanisms in schizophrenia, e.g. recruiting broader cortical areas to perform identical tasks. Similarly, neuroimaging studies of cognitive remediation in schizophrenia focus differentially on structural, functional and connectivity changes. Cognitive remediation improvements have been reported in two main areas: the prefrontal and thalamic regions. It has been suggested that those changes imply a functional reorganisation of neural networks, and cognitive remediation interventions might have a neuroprotective effect. Future studies should use multimodal neuroimaging procedures and more complex theoretical models to identify, confirm and clarify these and newer outcomes. This chapter highlights neuroimaging findings in anatomical and functional brain correlates of schizophrenia, as well as its application and potential use for identifying brain changes after cognitive remediation.


Schizophrenia Neuroimaging Functional brain correlates Cognitive remediation Hippocampus 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rafael Penadés
    • 1
    Email author
  • Nicolas Franck
    • 2
  • Laura González-Vallespí
    • 3
  • Marie Dekerle
    • 4
  1. 1.Hospital Clínic BarcelonaIDIBAPS, CIBERSAM, University of BarcelonaBarcelonaSpain
  2. 2.Centre Ressource de Réhabilitation Psychosociale et Remédiation Cognitive, UMR 5229 CNRS, Centre Hospitalier Le VinatierUniversity of LyonLyonFrance
  3. 3.Consorci Sanitari del MaresmeMataróSpain
  4. 4.Centre Ressource de Réhabilitation Psychosociale et Remédiation CognitiveLyonFrance

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