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Biocompatible and Biodegradable Chitosan Composites in Wound Healing Application: In Situ Novel Photo-Induced Skin Regeneration Approach

  • Amr A. EssawyEmail author
  • Hassan Hefni
  • A. M. El-Nggar
Chapter

Abstract

Biocompatible and biodegradable polymers have a significant impact in a wide range of biomedical applications such as wound healing. For this purpose, demanded materials must have, a specific physical, chemical, biological, biomechanical properties and able to be broken down and removed after they have served their function to provide effective therapy. In the recent progress of biomedical treatment of wounds, there is a continuous need to improve both the appearance and functionality of the regenerated healed tissue. Modern clinical findings in that approach make use of the versatility, efficacy and functionality of chitosan composites. This chapter presents an overview of biocompatible and biodegradable polymers focusing on chitosan-based composites, underlying concepts of their properties and the ways to tailor their potential in biomedical engineering/management of wound healing. However, providing novel strategies that achieve a low cost and shorter wound closure is an ongoing challenge to be addressed. Finally, new insights concluded from our recent study cases reports for novel chitosan grafted poly (N-methyl aniline) nanoparticles that show an advanced therapeutic dressing via interesting photo-therapy results within a promising photo-driven skin regeneration under visible-light irradiation. The photoactive surface of grafted chitosan could produce reactive oxidizing species by which infectious microorganisms could be killed. Therefore, the wounded tissues are repaired and regenerated.

Keywords

Chitosan Biocompatible/biodegradable polymers Biomedical application Wound healing Phototherapy 

List of Abbreviations

Aw

Water absorbency

CCNC

Chitosan-based copper nanocomposite

CF

Chitosan-fibrin

CFU

Colony-forming unit

CMCS

Carboxymethyl chitosan

COX-2

Cyclooxygenase-2

CS-Ag

Chitosan-Ag

CSNPs

Chitosan nanoparticles

CZBs

Chitosan hydrogel/nano-ZnO nanocomposite bandages

DA

Deacetylation

DC

Decoloration

DM

Demineralization

DP

Degree of polymerization

DP

Deproteinization

ECM

Extracellular matrix

FDA

American Food and Drug Administration

FTIR

Fourier transform infrared

IL

Interleukin

LPS

Lipopolysaccharide

Mel/CS MS

Melatonin-loaded chitosan-based microspheres

MW

Molecular weight

MyD88

Myeloid differentiation primary-response protein 88

NF-κB

Nuclear factor-kappa

NMR

Nuclear magnetic resonance

nT/COL-CS

Nano-titania/collagen-chitosan

PVA

Polyvinyl alcohol

Q-CF

Quercetin-loaded chitosan–fibrin

ROS

Reactive oxygen species

SSD

Silver sulfadiazine

TLR-4

Toll-like receptor 4

TMC

N,N,N-Trimethyl chitosan

TNF-α

Tumor necrosis factor-alpha

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Amr A. Essawy
    • 1
    • 2
    Email author
  • Hassan Hefni
    • 3
  • A. M. El-Nggar
    • 4
  1. 1.Chemistry Department, Faculty of ScienceFayoum UniversityFayoumEgypt
  2. 2.Chemistry Department, College of ScienceJouf UniversitySakakaKingdom of Saudi Arabia
  3. 3.Petrochemicals DepartmentEgyptian Petroleum Research Institute (EPRI)CairoEgypt
  4. 4.Chemistry Department, Faculty of ScienceAl-Azhar UniversityCairoEgypt

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