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Metabolomic Approaches in Vitamin E Research

  • John K. LodgeEmail author
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

Metabolomics aims to characterise changes to the complement of metabolites in a biological sample (metabolome), and this technology is gaining interest in nutrition research as it can define perturbations to metabolism induced by dietary factors. There have been a number of metabolomic studies in human and animal models based around vitamin E supplementation or deficiency that have highlighted potential areas in metabolism that vitamin E may play a role. In humans, vitamin E supplementation has been shown to influence phospholipid metabolism and amino acid metabolism, and discriminatory metabolites have included several vitamin E metabolites. Proteomic studies looking at associations with vitamin E concentrations have demonstrated consistent relationships with several apoproteins. Metabolomic studies in animal models include studies on zebrafish foetal development that showed changes to antioxidant status and lipid peroxidation with vitamin E deficiency and rodent models of vitamin E deficiency that showed influences on central metabolism. Metabolomics has proven to be a useful research tool to identify novel functions of vitamin E.

Keywords

Metabolomics Proteomics Vitamin E Metabolites Human Animal 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Applied Sciences, Faculty of Health and Life SciencesNorthumbria UniversityNewcastle upon TyneUK

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