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Future Directions

  • Mandeep S. Singh
  • Marco A. Zarbin
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Several phase 1/2 clinical trials have focused on investigating the safety and feasibility of retinal cell therapy in diseases such as age-related macular degeneration, retinitis pigmentosa, and Stargardt disease. Technical improvements are anticipated in areas such as surgical delivery methods, composite cellular patches, and synthetic basement substrates for optimal retinal protection and regeneration. Immunosuppression protocols are being optimized in order to avoid the side effects of long-term systemic immunosuppression. The development of appropriate clinical trial endpoints will facilitate assessment of the efficacy of retinal stem cell therapy in phase 3 clinical trials. Greater regulatory oversight and public education are needed to eliminate the dangers associated with direct-to-consumer cell therapy, so that the progress of properly designed and supervised clinical trials is not impeded.

Keywords

Cell therapy Clinical trials Age-related macular degeneration Retinitis pigmentosa Stargardt disease Immunosuppression Surgical delivery Regulatory oversight 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mandeep S. Singh
    • 1
  • Marco A. Zarbin
    • 2
  1. 1.Wilmer Eye Institute, Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical SchoolNewarkUSA

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