Robust Modality Selection in Radiotherapy
External beam radiotherapy attempts to maximize tumor-damage while limiting toxicity on healthy tissue. Although several modalities with distinctive biological and physical properties are available, none is dominant. A mathematical formulation for optimal modality selection with uncertainty in these properties is presented. Uncertainty is incorporated via a robust approach. The problem decomposes into finitely many subproblems with analytically solvable Karush-Kuhn-Tucker conditions. Numerical experiments demonstrate how uncertainty affects optimal solutions even when clinical intuition is not readily available.
This research was funded in part by the National Science Foundation via grant CMMI #1560476.
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