Abstract
The importance of Acacia plants in animal nutrition and in the prevention and treatment of human and animal diseases has been recognized for centuries. Babool extract, obtained from Acacia nilotica (also known as gum Arabica tree), is very rich in secondary metabolites such as tannins, flavonoids, alkaloids, terpenes, fatty acids, etc. These compounds exert antioxidative, anti-inflammatory, anthelmintic, antidiarrheal, antispasmodic, antihypertensive, antibacterial, antifungal, antidiabetic, antiplatelet aggregatory, antiplasmodial, antimutagenic, anticancer, acetylcholinesterase-inhibiting, diuretic, antipyretic, analgesic, and many other effects. This chapter describes various aspects of babool with special emphasis on its nutritional value and applications in prevention and treatment of diseases in animals.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abbas ZTEM, Elhag WI (2015) In vitro antibacterial activity of Acacia nilotica methanolic extract against wound infection pathogen. Am J Res Commun 3:111–121
Abbasian K, Asgarpanah J, Ziarati P (2015) Chemical composition profile of Acacia nilotica seed growing wild in south of Iran. Orient J Chem 31(2):1027–1033
Abdullah MAM, Farghaly MM, Youssef IMI (2018) Effect of feeding Acacia nilotica pods to sheep on nutrient digestibility, nitrogen balance, ruminal protozoa and rumen enzymes activity. J Anim Physiol Anim Nutr 102:662–669
Abuelgassim AO (2013a) Antioxidant potential of date palm leaves and Acacia nilotica fruit in comparison with other four common Arabian medicinal plants. Life Sci J 10:3405–3410
Abuelgassim AO (2013b) Effect of Acacia nilotica fruit extract on serum glucose and lipid concentrations in alloxan-induced diabetic rats. Pak J Biol Sci 16(21):1398–1402
Agunu A, Yusuf S, Andrew GO et al (2005) Evaluation of five medicinal plants used in diarrhea treatment in Nigeria. J Ethnopharmacol 101:27–30
Ahmad M, Zaman F, Sharif T et al (2008) Antidiabetic and hypolipidemic effects of aqueous methanolic extract of Acacia nilotica pods in alloxan-induced diabetic rabbits. Scand J Lab Anim Sci 35(1):29–34
Ahmadu A, Abdulkarim A, Grougnet R et al (2009) Two new peltogynoids from Acacia nilotica Delile with kinase inhibitory activity. Planta Med 75:1–3
Alli LA, Adesokan AA, Salawu OA et al (2011) Antiplasmodial activity of aqueous root extract of Acacia nilotica. Afr J Biochem Res 5:214–219
Alli LA, Nafiu MO, Adesokan AA et al (2014) Antipyretic and analgesic activities of aqueous extract of Acacia nilotica root. Biokemistri 26:55–62
Alli LA, Adesokan AA, Salawu OA, Akanji MA (2015) Toxicological studies of aqueous extract of Acacia nilotica root. Interdisc Toxicol 8(1):48–54
Alli A, Adesokan AA, Salawu AO (2016) Antimalarial activity of fractions of aqueous extract of Acacia nilotica root. J Intercult Ethnopharmacol 5(2):180–185
Al-Mustafa ZH (2000) A study on the toxicology of Acacia nilotica. Am J Chin Med 28:123–129
Amos S, Akah CJ, Odukwe KS, Wambede C (1999) The pharmacological effects of an aqueous extract from Acacia nilotica seeds. Phytother Res 13:683–685
Asad M, Munir TA, Afzal N (2011) Acacia nilotica leave extract and glyburide: comparison of fasting blood glucose, serum insulin, β-thromboglobulin levels and platelet aggregation in streptozotocin induced diabetic rats. J Pak Med Assoc 61:247–251
Bachaya HA, Iqbala Z, Khan MN et al (2009) Anthelmintic activity of Ziziphus nummularia (bark) and Acacia nilotica (fruit) against Trichostrongylid nematodes of sheep. J Ethnopharmacol 123:325–329
Bansal VK, Goel RK (2012) Gastroprotective effect of Acacia nilotica young seedless pod extract: role of polyphenolic constituents. Asian Pac J Trop Med 5:523–528
Banso A (2009) Phytochemical and antibacterial investigation of bark extracts of Acacia nilotica. J Med Pants Res 3:82–85
Bapna S, Ramaiya M, Chowdhary A (2014) Antimalarial potential of plants used as chewing sticks for oral hygiene in rural areas of Rajasthan, India. Am J Ethnomed 1:319–325
Bargali K, Bargali SS (2009) Acacia nilotica: a multipurpose leguminous plant. Nat Sci 7(4):11–19
Bashir HS, Mohammed AM, Magsoud AS et al (2014) Isolation and identification of two flavonoids from Acacia nilotica (Leguminoseae) leaves. J Forst Prod Indust 3(5):211–215
Bhakuni DS, Dhar ML, Dhar MM et al (1969) Screening of Indian plants for biological activity. Part II. Indian J Exp Biol 7:250–262
Bhargava A, Srivastava A, Kumbhare VC (1998) Antifungal activity of polyphenolic complex of Acacia nilotica bark. Indian Forest 124:292–298
Bushra S, Farooq A, Roman P (2007) Antioxidant activity of phenolic components present in barks of Azarichta indica, Terminalia arjuna, and Acacia nilotica, and Eugenia jambolana Lam trees. Food Chem 104(3):148–161
Chalk RC, Stoddart JF, Szarek WA et al (1968) Isolation of two arabinobioses from Acacia nilotica gum. Can J Chem 46:2311–2313
Chaubal R, Mujumdar AM, Puranik VG et al (2003) Isolation and X-ray study of an anti-inflammatory active androstene steroid from Acacia nilotica. Planta Med 69:287–288
Chaubal R, Pawar PV, Hebbalkar GD et al (2005) Larvicidal activity of Acacia nilotica extracts and isolation of p-pinitol-a bioactive carbohydrate. Chem Biodivers 2:684–688
Chauhan D, Singh J, Siddiqui IR (2000) Isolation of two flavonol glycosides from the seeds of Acacia nilotica. Indian J Chem 39(B):719–722
Dafallah AA, Al-Mustafa Z (1996) Investigation of the anti-inflammatory activity of Acacia nilotica and Hibiscus sabdariffa. Am J Chin Med 24:263–269
Dev SNC, De K, Singh S (2014) Antimicrobial activity and phytochemical analysis of Acacia nilotica (L.) Del. Indian J Appl Pure Biol 29:331–332
Eldeen IMS, Elgorashi EE, Staden J (2005) Antibacterial, anti-inflammatory, and anti-cholinesterase and mutagenic effects of extracts from some trees used in South African traditional medicine. J Ethnopharmacol 102:457–464
Eldeen IM, Heerden V, Staden JV (2010) In vitro biological activities of niloticane, a new bioactive cassane diterpene from the bark of Acacia nilotica subsp. kraussiana. J Ethnopharmacol 128:555–560
Elizabeth KM, Sireesha D, Rao KN et al (2005) Antimicrobial activity of Acacia nilotica. Asian J Chem 18:191–195
El-Tahir A, Satti GMH, Khalid SA (1999) Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Acacia nilotica. Phytother Res 13:474–478
El-Toumy SA, Mohamed SM, Hassan EM et al (2011) Phenolic metabolites from Acacia nilotica flowers and evaluation of its free radical scavenging activity. J Am Sci 7:287–295
Fatima S, Baig MR, Baig M et al (2012) Antimicrobial activity of Acacia nilotica (L.) Del. Plant extract against Xanthomonas malvacearum bacteria. Int Multidiscipl Res J 2:48–49
Gilani AH, Shaheen F, Zaman M et al (1999) Studies on antihypertensive and antispasmodic activities of methanol extract of Acacia nilotica pods. Phytother Res 13:665–669
Hussein A (1982) Molluscicidal properties of Acacia nilotica. Planta Med 46:181–183
Hussein Ayoub SM (1982) Molluscicidal properties of Acacia nilotica subspecies tomentosa and astringens II. J Trop Med Hyg 88(3):201–203
Hussein G, Miyashiro H, Nakamura N et al (2000) Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus (HCV) protease. Phytother Res 14:510–516
Ibrahim AM, Phillipson JD, Warhurst DC et al (1991) The potential antimalarial activity of some Sudanese plants. Trans Roy Soc Trop Med Hyg 85:310–318
Jangade NM, Nagargoje PB, Shirote PJ (2014) Isolation, phytochemical and biological evaluation of Acacia nilotica (L.) Wild. leaf extract. Int J Pharmacog Phytochem Res 6:179–182
Jigam AA, Akanya HO, Ogbadoyi EO et al (2010) In vivo antiplasmodial, analgesic and anti-inflammatory effects of the root extracts of Acacia nilotica Del (Leguminoseae). Asian J Exp Biol Sci 1:315–320
Kalaivani T, Mathew L (2010) Free radical scavenging activity from leaves of Acacia nilotica (L.) Wild. ex Delile, an Indian medicinal tree. Food Chem Toxicol 48:298–305
Kannan LN, Sakthivel KM, Guruvayoorappan C (2013) Protective effect of Acacia nilotica (L.) against acetaminophen-induced hepatocellular damage in Wistar rats. Adv Pharmacol Sci 2013:987692
Karau GM (2013) Biosprospecting of antidiabetic compounds from selected medicinal plants for the management of diabetes mellitus in Mbeere and Meru, Kenya. PhD Thesis
Khalid SA, Yagi SM, Khritova P et al (1989) (+)-Catechin-5-galloyl ester as a novel natural polyphenol from the bark of Acacia nilotica of Sudanese origin. Planta Med 55:556–558
Krishna PSR, Lavanya B, Sireesha P et al (2011) Comparative study of Acacia nilotica and Acacia sinuata for diuretic activity. Der Pharmacia Sinc 2(6):17–22
Krowch CM, Okello EJ (2009) Kinetics of acetylcholinesterase inhibitory activities by aqueous extracts of Acacia nilotica (L.) and Rhamnus prinoides (L’Hér.). Afr J Pharm Pharmacol 3:469–475
Kumari M, Jain S, Dave R (2014) Babul (Acacia nilotica) a potential source of tannin and its suitability in management of type II diabetes. Nutr Food Sci 44(2):116–119
Liu X, Kim J-K, Li Y et al (2005) Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. Am Soc Nutr Sci 135:165–171
Lompo-Ouedraogo Z, van der Heide D, van der Beek EM et al (2004) Effect of aqueous extract of Acacia nilotica ssp adansonii on milk production and prolactin release in the rat. J Endocrinol 182:257–266
Malan E (1991) Derivatives of (+)-catechin-5-gallate from the bark of Acacia nilotica. Phytochemistry 30:2737–2739
Malviya S, Rawat S, Kharia A, Varma M (2011) Medicinal attributes of Acacia nilotica Linn. A comprehensive review on ethnopharmacological claims. Int J Pharm Life Sci 2(6):830–837
Mangan J (1988) Nutritional effects of tannins in animal feeds. Nutr Res Rev 1:209–231
Mbatchou VC, Oumar AA (2012) Antifungal activity of nilobamate isolated from Acacia nilotica Wild. Phytopharmacology 3:208–213
Meena PD, Kaushik P, Shukla S et al (2006) Anticancer and antimutagenic properties of Acacia nilotica (Linn.) on 7,12-dimethylbenz(a)anthracene-induced skin papillomagenesis in Swiss albino mice. Asian Pac J Cancer Prev 7(4):627–632
Misar A, Bhagat R, Mujumdar AM (2008) Antidiarrheal activity of Acacia nilotica Wild. bark methanol extract. Hindustan Antibiot Bull 50:14–20
Mlambo V (2003) Modifying the nutritional effects of tannins present in Acacia and other tree fruits offered as protein supplements to goats in Zimbabwe. PhD Thesis, University of Reading, Reading, UK, p 273
Mohamed LT, Bushra EIS, Abdelrahman MN (2010) The antibacterial, antiviral activities and phytochemical screening of some Sudanese medicinal plants. Eur Asian J Biosci 4:8–16
Mohan S, Thiagarajan K, Chandrasekaran R et al (2014) In vitro protection of biological macromolecules against oxidative stress and in vivo toxicity evaluation of Acacia nilotica (L.) and ethyl gallate in rats. BMC Complement Altern Med 14:257–270
Mousa M (2011) Effect of feeding acacia as supplements on the nutrient digestion, growth performance, carcass traits and some blood constituents of Awassi lambs under the conditions of North Sinai. Asian J Anim Sci 5:102–117
Mueller H (2006) Unravelling the conundrum of tannins in animal nutrition and health. J Sci Food Agr 86:2010–2037
Mustafa NK, Tanira MOM, Dar FK et al (1999) Antimicrobial activity of Acacia nilotica subsp. nilotica fruit extracts. Pharm Pharmacol Commun 5:583–586
Oladosu P, Isu NR, Ibrahim K et al (2013) Time kill-kinetics antibacterial study of Acacia nilotica. Afr J Microbiol 7:5248–5252
Omara EO, Nadab SA, Farraga ARH et al (2012) Therapeutic effect of Acacia nilotica pods extract on streptozotocin induced diabetic nephropathy in rat. Phytomedicine 19(12):1059–1067
Pai MBP, Prashant GM, Murlikrishna KS et al (2010) Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study. Indian J Dent Res 21:334–336
Pareek P, Choudhry M (2013) Management of type 2 diabetics by Indian gum arabic (Acacia nilotica) pods powder. Int J Food Nutr Sci 2(2):77–83
Paswan JK, Kumar K, Kumar S et al (2016) Effect of feeding Acacia nilotica pod meal on hematobiochemical profile and fecal egg count in goats. Vet World 9:1400–1406
Prakash L, Garg G (1981) Chemical constituents of the roots of Millingtonia hortensis L. and Acacia nilotica (L.) Del. J Indian Chem Soc 58:96–97
Prathapa Reddy M, Shantha TR, Naveen Kumar SP et al (2018) Pharmacognostical studies on fruits of babbula-Acacia nilotica (L.) Delile. Int J Herbal Med 6(2):115–120
Rahaman O (2010) A review of uses Acacia nilotica (Booni) in alternative medicine. SearchWarp.com
Raheel R, Ashraf M, Ejaz S et al (2013) Assessment of the cytotoxic and antiviral potential of aqueous extracts from different parts of Acacia nilotica (Linn) Delile against Peste des petits ruminants virus. Environ Toxicol Pharmacol 35:72–81
Rai SP, Prasad MS, Singh K (2014) Evaluation of the antifungal activity of the potent fraction of hexane extract obtained from the bark of Acacia nilotica. Int J Sci Res 3:730–738
Rajbir S, Bikram S, Sukhpreet K et al (2010) Umbelliferone-an antioxidant isolated from Acacia nilotica (L.) Wild. ex Del. Food Chem 120(3):825–830
Rajvaidhya S, Nagori BP, Singh GK et al (2015) A review of Acacia arabica – an Indian medicinal plant. Int J Pharmaceut Sci Res 1.11:90.2
Rana D (2018) A review of ethnomedicine, phytochemical and pharmacological properties of Acacia nilotica (babool/kikar). Int J Biol Pharmac Allied Sci 7(5):856–863
Rani P, Khullar N (2004) Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi. Phytother Res 18:670–673
Rasool N, Tehseen H, Riaz M et al (2013) Cytotoxicity studies and antioxidant potential of Acacia nilotica roots. Int J Chem Biochem Sci 3:34–41
Rather LJ, Islam S-U, Mohammad F (2015) Acacia nilotica (L.): a review of its traditional uses, phytochemistry, and pharmacology. Sustain Chem Pharm 2:12–30
Roozbeh N, Darvish L, Abdi F (2017) Hypoglycemic effects of Acacia nilotica in type II diabetes: a research proposal. BMC Res Notes 10:331
Safari VZ, Kamau JK, Nthiga PM et al (2016) Antipyretic, anti-inflammatory and antinociceptive activities of aqueous bark extract of Acacia nilotica (L.) Delile in albino mice. J Pain Manage Med 2(2):113
Saini ML, Saini R, Roy S et al (2008) Comparative pharmacognostical and antimicrobial studies of acacia species (Mimosaceae). J Medic Plant Res 2(12):378–386
Sakthivel KM, Kannan N, Angeline A et al (2012) Anticancer activity of Acacia nilotica (L.) Wild ex. Delile subsp. indica against Dalton’s ascitic lymphoma induced solid and ascitic tumor model. Asian Pac J Cancer Prev 13(8):3989–3995
Sawadogo L, Sepehri H, Houdebine LM (1989) Mise en evidence d’un facteur stimulant la sécrétion de PRL et d’hormone de croissance dans la drè che de brasserie. Reprod Nutr Dev 29:139–146
Scalbert A (1991) Antimicrobial properties of tannins. Phytochemistry 30:3875–3883
Shah BH, Safdar B, Virani SS et al (1997) The antiplatelet aggregatory activity of Acacia nilotica is due to blockade of calcium influx through membrane calcium channels. Gen Pharmacol 29:251–255
Shanker K, Krishna MG, Bhagavan RM et al (2014) Efficacy of leaves extract of Acacia nilotica against Pseudomonas aeruginosa with reference to disc diffusion method. Res J Pharmacogn Phytochem 6:96–98
Sharma A, Sankhla B, Parker SM et al (2014a) Effect of traditionally used neem and babool chewing stick (datum) on Streptococcus mutans: an in vitro study. J Clin Diagn Res 8(7):ZC15–ZC17
Sharma C, Aneja KR, Surain P et al (2014b) In vitro evaluation of antimicrobial spectrum of Acacia nilotica leaves and bark extracts against pathogens causing otitis infection. J Innov Biol 1(1):051–056
Singh R, Arora S (2007) Attenuation of free radicals by acetone extract/fraction of Acacia nilotica Wild (L.) ex Del. J Chin Clin Med 2:196–203
Singh R, Singh B, Singh S et al (2008) Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Wild. ex. Del. Toxicol In Vitro 22(8):1965–1970
Singh BN, Singh BR, Singh RL et al (2009a) Antioxidant and anti-quorum sensing activities of green pods of Acacia nilotica L. Food Chem Toxicol 47:778–786
Singh BN, Singh BR, Sarma BK et al (2009b) Potential chemoprevention of N-nitrosodiethylamine- induced hepato-carcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact 181(1):20–28
Singh R, Singh B, Singh S et al (2010) Umbelliferone-an antioxidant isolated from Acacia nilotica (L.) Wild. ex Del. Food Chem 120:825–830
Sokeng SD, Koubé J, Dongmo F et al (2013) Acute and chronic anti-inflammatory effects of the aqueous extract of Acacia nilotica (L.) Del. (Fabaceae) pods. Acad J Med Plants 1:001–005
Sonibare MA, Gbile ZO (2008) Acacia nilotica is good for the treatment of asthma. Afr J Tradit Complement Altern Med 5:345
Srivastava M, Kumar G, Mohan R et al (2014) Phytochemical studies and antimicrobial activity of babool seeds. J Sci Ind Res 73:724–728
Sultana B, Anwar F, Przybylski R (2007) Antioxidant activity of phenolic components present in bark of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. trees. Food Chem 104:1106–1114
Sundaram R, Mitra SK (2007) Antioxidant activity of ethyl acetate soluble fraction of Acacia nilotica bark in rats. Indian J Pharmacol 39:33–38
Sundarraj S, Thangam R, Sreevani V et al (2012) γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J Ethnopharmacol 141(3):803–809
Tanko Y, Abdulazeez A, Muhammad A et al (2014) Effect of methanol crude leaves extract and aqueous fraction of Acacia nilotica on lipid profile and liver enzymes on alloxan-induced diabetic rats. Ann Exp Biol 2:36–40
Umaru B, Mahre S, Dogo HM et al (2016) Effects of aqueous pod extract of Acacia nilotica on white blood cells, platelets and clotting time in albino rats. Am J Pharmacol Pharmacother 3(3):1–6
Vadivel V, Biesalski HK (2012) Total phenolic content, in vitro antioxidant activity and type II diabetes relevant enzyme inhibition properties of methanolic extract of traditionally processed underutilized food legume, Acacia nilotica (L.) Wild ex. Delile. Int Food Res J 19(2):593–601
Vanden Berghe DA, Vlietinck AJ, Van Hoof L (1986) Plant products as potential antiviral agents. Bull de l’institut Pasteur 84:101–147
Vijayasanthi M, Kannan V, Venkataswamy R, Doss A (2011) Evaluation of the antibacterial potential of various solvent extracts of Acacia nilotica Linn. leaves. J Drug Med 4:91–96
Vlietinck AJ, Vanden Berghe DA (1991) Can ethnopharmacology contribute to the development of antiviral drugs. J Ethnopharmacol 32:141–153
Vlietinck AJ, de Bruyne T, Vanden Berghe DA (1997) Plant substances as antiviral agents. Curr Organ Chem 1:307–344
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Gupta, R.C., Doss, R.B., Lall, R., Sinha, A., Srivastava, A., Malik, J.K. (2019). Babool (Acacia nilotica). In: Gupta, R., Srivastava, A., Lall, R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-04624-8_8
Download citation
DOI: https://doi.org/10.1007/978-3-030-04624-8_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-04623-1
Online ISBN: 978-3-030-04624-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)