Advertisement

Plant and Food Derived Immunomodulators as Nutraceuticals for Performance Enhancing Activities

  • Bhanushree Gupta
  • Vidya Rani Singh
  • Surabhi Verma
  • Neha Meshram
  • Leena Dhruw
  • Rahul Sharma
  • Kallol K. Ghosh
  • Ramesh C. Gupta
Chapter

Abstract

The progress in research has prompted a new age for food- and plant-derived products that are of incredible benefit and are widely utilized as immunomodulators and vitality supporters in the form of nutraceuticals. They are even being regarded as agents with the potential to cure numerous diseases. These functional products are processed from plants in the form of phytochemicals, as well as from food sources such as soy products, mushrooms, and milk. A considerable number of these nutraceuticals have relevant physiological functions and important biological activities. The present aggregated information about nutraceuticals undoubtedly provides extraordinary opportunities for use by nutritionists, doctors, food technologists, and chemists.

Keywords

Immunomodulators Bioactive peptides Nutraceuticals Nutritional food Performance-enhancing nutraceuticals 

References

  1. Alhaj OA, Kanekanian AD, Peters AC et al (2010) Hypocholesterolaemic effect of Bifidobacterium animalis subsp. lactis (Bb12) and trypsin casein hydrolysate. Food Chem 123(2):430–435CrossRefGoogle Scholar
  2. Bargeman G, Koops GK, Houwing J et al (2002) The development of electromembrane filtration for the isolation of bioactive peptides: the effect of membrane selection and operating parameters on the transport rate. Desalination 149(1e3):369–374CrossRefGoogle Scholar
  3. Baxter D (2007) Active and passive immunity, vaccine types, excipients and licensing. Occup Med 57:552–556CrossRefGoogle Scholar
  4. Bhaumik S, Jyothi MD, Khar A (2000) Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Lett 483:78–82CrossRefGoogle Scholar
  5. Bouhallab S, Bouglé D (2011) Mineral-binding peptides from food. In: Hettiarachchy NS, Sato K, Marshall MR, Kannan A (eds) Bioactive food proteins and peptides: applications in human health. CRC Press, Boca Raton, FL, pp 117–130CrossRefGoogle Scholar
  6. Caterina MJ, Schumacher MA, Tominaga M et al (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824CrossRefGoogle Scholar
  7. Chabeaud A, Vandanjon L, Bourseau P et al (2009) Performances of ultrafiltration membranes for fractionating a fish protein hydrolysate: application to the refining of bioactive peptide fractions. Sep Purif Technol 66(3):463–471CrossRefGoogle Scholar
  8. Chauhan B, Kumar G, Kalam N et al (2013) Current concepts and prospects of herbal nutraceutical: a review. J Adv Pharm Technol Res 4(1):4–8CrossRefGoogle Scholar
  9. DeFelice SL (1992) The nutraceutical initiative: a recommendation for US economic and regulatory reforms. Genet Eng News 12:13–15Google Scholar
  10. Dhir H, Roy AK, Sharma A et al (1991) Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by Phyllanthus emblica fruit extract. Mutation Res 24:305–312Google Scholar
  11. Dominic A, Danquah MK (2012) Rethinking food-derived bioactive peptides for antimicrobial and immunomodulatory activities. Trends Food Sci Technol 23(2):62–69CrossRefGoogle Scholar
  12. Fürst P, Kuhn KS (2000) Fish oil emulsions: what benefits can they bring? Clin Nutr 19:7–14CrossRefGoogle Scholar
  13. Gill HS, Doull F, Rutherfurd KJ et al (2000) Immunoregulatory peptides in bovine milk. Br J Nutr 84(Suppl. 1):S111–S117CrossRefGoogle Scholar
  14. Gobbetti M, Minervini F, Rizzello CG (2007) Bioactive peptides in dairy products. In: Hui YH (ed) Handbook of food products manufacturing. Wiley, HobokenGoogle Scholar
  15. Hartmann R, Gunther S, Martin D et al (2000) Cytochemical model systems for the detection and characterization of potentially bioactive milk components. Kiel Milchwirtschaftliche Forschungsberichte 52:61–85Google Scholar
  16. Hirota Y, Yang MP (1995) Enhancing effect of chicken egg white derivatives on the phagocytic response in the dog. J Vet Med Sci 57(5):825–829CrossRefGoogle Scholar
  17. Ito T, Warnken SP, May SW (1999) Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2 alpha kinases. Biochem Biophys Res Commun 265:589–594CrossRefGoogle Scholar
  18. Jantan I, Ahmad W, Nasir S, Bukhari NS (2015) Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci 6:655.  https://doi.org/10.3389/fpls.2015.00655 CrossRefPubMedPubMedCentralGoogle Scholar
  19. Khandelwal S, Shukla LJ, Shanker R (2002) Modulation of acute cadmium toxicity by Emblica offıcinalis fruit in rat. Ind J Exp Biol 40:564–570Google Scholar
  20. Kim S, Shin HJ, Kim SY et al (2004) Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPAR alpha. Mol Cell Endocrinol 220:51–58CrossRefGoogle Scholar
  21. Korhonen H, Pihlanto A (2006) Bioactive peptides: production and functionality. Int Dairy J 16(9):945–960CrossRefGoogle Scholar
  22. Kumar RA, Sridevi K, Kumar NV et al (2004) Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 92:291–295CrossRefGoogle Scholar
  23. Lerman A, Lockwood B (2007) Nutraceuticals in veterinary medicine. Pharm J 278:51–55Google Scholar
  24. Licciardi PV, Underwood JR (2011) Plant-derived medicines: a novel class of immunological adjuvants. Int Immunopharmacol 11(3):391–398CrossRefGoogle Scholar
  25. Macdonald RS, Thornton WH, Marshall RT (1994) A cell culture model to identify biologically active peptides generated by bacterial hydrolysis of casein. J Dairy Sci 77:1167–1175CrossRefGoogle Scholar
  26. Middleton E, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673–751PubMedGoogle Scholar
  27. Nguyen TV, Yuvan L, Saif LJ et al (2007) Transfer of maternal cytokines to suckling piglets: in vivo and in vitro models with implications for immunomodulation of neonatal immunity. Vet Immunol Immunopathol 117:236–248CrossRefGoogle Scholar
  28. Orlando JM (2018) Behavioral nutraceuticals and diets. Vet Clin N Am Small Anim Pract 48:473–495CrossRefGoogle Scholar
  29. Otani H, Kihara Y, Park M (2010) The immunoenhancing property of dietary casein phosphopeptide preparation in mice. Food Agr Immunol 12:165–173CrossRefGoogle Scholar
  30. Park YW (ed) (2009) Bioactive components in milk and dairy products. Wiley, HobokenGoogle Scholar
  31. Pedroche J, Yust MM, Lqari H et al (2007) Obtaining of Brassica carinata protein hydrolysates enriched in bioactive peptides using immobilized digestive proteases. Food Res Int 40(7):931–938CrossRefGoogle Scholar
  32. Petrillo EW Jr, Ondetti MA (1982) Angiotensin converting enzyme inhibitors: medicinal chemistry and biological actions. Med Res Rev 2:1–41CrossRefGoogle Scholar
  33. Phelan M, Aherene A, Fitz Gerald RJ et al (2009) Casein-derived bioactive peptides: biological effects, industrial uses, safety aspects and regulatory status. Int Dairy J 19:643–654CrossRefGoogle Scholar
  34. Pihlanto A (2006) Antioxidative peptides derived from milk proteins. Int Dairy J 16:1306–1314CrossRefGoogle Scholar
  35. Rabinovitch A, Suarez-Pinzon WL, Sorensen O et al (1996) Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137(5):2093–2099CrossRefGoogle Scholar
  36. Roy MK, Watanabe Y, Tami Y (1999) Induction of apoptosis in HL-60 cells by skimmed milk digested with a proteolytic enzyme from the yeast Saccharomyces cerevisiae. J Biosci Bioeng 88:426–432CrossRefGoogle Scholar
  37. Ryan JT, Ross RP, Bolton D et al (2011) Bioactive peptides from muscle sources: meat and fish. Nutrients 3:765–791CrossRefGoogle Scholar
  38. Sethiya NK, Alok N, Dixit VK et al (2011) Cognition boosting effect of Canscoradecussata (a South Indian Shankhpushpi). Eur J Integr Med 4:113–121. ELSEVIERCrossRefGoogle Scholar
  39. Shahidi F, Zhong Y (2008) Bioactive peptides. J AOAC Int 91(4):914–931PubMedGoogle Scholar
  40. Sharma S, Singh R, Rana S (2011) Bioactive peptides: a review. Int J Bioautomation 15(4):223–250Google Scholar
  41. Surh YJ, Chun KS, Cha HH et al (2001) Molecular mechanisms underlying chemopreventive activities of antiinflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-activation. Mutat Res 481:243–268CrossRefGoogle Scholar
  42. Vaibhav K, Shrivastava P, Javed H et al (2012) Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Mol Cell Biochem 367:73–84CrossRefGoogle Scholar
  43. Vang O, Ahmad N, Baile CA et al (2011) What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLos One 6(6):e19981CrossRefGoogle Scholar
  44. Wang Z, Lee Y, Eun JS et al (2014) Inhibition of adipocyte inflammation and macrophage chemotaxis by butein. Eur J Pharmacol 738:40–48CrossRefGoogle Scholar
  45. Wong CW, Seow HF, Husband AJ et al (1997) Effects of purified bovine whey factors on cellular immune functions in ruminants. Vet Immunol Immunopathol 56:85–96CrossRefGoogle Scholar
  46. Yada T, Uchida K, Kajimura S et al (2002) Immunomodulatory effects of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. J Endocrinol 173:483–492CrossRefGoogle Scholar
  47. Youn J, Lee JS, Na HK et al (2009) Resveratrol and piceatannol inhibit iNOS expression and NF-κB activation in dextran sulfate sodium--induced mouse colitis. Nutr Cancer 61:847–854CrossRefGoogle Scholar
  48. Yu L, Yang L, An W et al (2014) Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells. J Cell Biochem 115(4):697–711CrossRefGoogle Scholar
  49. Zhang L, Guang Li C, Liang H et al (2017) Bioactive mushroom polysaccharides: immunoceuticals to anticancer agents. J Nutr Food Sci 2:1–5Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bhanushree Gupta
    • 1
  • Vidya Rani Singh
    • 1
  • Surabhi Verma
    • 1
  • Neha Meshram
    • 1
  • Leena Dhruw
    • 1
  • Rahul Sharma
    • 2
  • Kallol K. Ghosh
    • 3
  • Ramesh C. Gupta
    • 4
  1. 1.Department of Chemistry, Center for Basic SciencesPandit Ravishankar Shukla UniversityRaipur (C.G.)India
  2. 2.Department of Plant Physiology, Agricultural Biochemistry, Medicinal and Aromatic PlantsIndira Gandhi Agricultural UniversityRaipur (C.G.)India
  3. 3.School of Studies in ChemistryPandit Ravishankar Shukla UniversityRaipur (C.G.)India
  4. 4.Toxicology Department, Breathitt Veterinary CenterMurray State UniversityHopkinsvilleUSA

Personalised recommendations