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Link Between Receptors That Engage in Developing Vasospasm After Subarachnoid Hemorrhage in Mice

  • Fumi NakanoEmail author
  • Fumihiro Kawakita
  • Lei Liu
  • Yoshinari Nakatsuka
  • Hirofumi Nishikawa
  • Takeshi Okada
  • Masato Shiba
  • Hidenori Suzuki
Chapter
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 127)

Abstract

Vasospasm after subarachnoid hemorrhage (SAH) has been studied, but the mechanisms remain to be unveiled. Tenascin-C (TNC), which is a matricellular protein and reported to increase in spastic cerebral artery wall after SAH, is a ligand for both Toll-like receptor 4 (TLR4) and epidermal growth factor receptor (EGFR). Our previous studies suggested the involvement of TNC and these receptors in vasoconstriction or vasospasm after SAH. In this study, we investigated whether upregulation of TNC and TLR4 is observed and if an EGFR inhibitor has suppressive effects against them in a mice endovascular perforation SAH model. At 24 h after SAH, TNC and TLR4 expressions were widely observed in spastic cerebral arteries, and these expressions were suppressed by the administration of an EGFR inhibitor. From these results, EGFR inhibitors possibly suppress the expression of not only EGFR but also TLR4 at least partly through regulating TNC upregulation. More studies are needed to clarify the precise mechanisms linking these receptors.

Keywords

Epidermal growth factor receptor Toll-like receptor 4 Tenascin-C Cerebral vasospasm 

Notes

Acknowledgments

This work was supported in part by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science to Drs. Shiba and Suzuki. We thank Chiduru Yamamoto (Department of Neurosurgery, Mie University Graduate School of Medicine) for her assistance.

Conflict of Interest: The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Fumi Nakano
    • 1
    Email author
  • Fumihiro Kawakita
    • 1
  • Lei Liu
    • 1
  • Yoshinari Nakatsuka
    • 1
  • Hirofumi Nishikawa
    • 1
  • Takeshi Okada
    • 1
  • Masato Shiba
    • 1
  • Hidenori Suzuki
    • 1
  1. 1.Department of NeurosurgeryMie University Graduate School of MedicineTsuJapan

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