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Role of Computational Fluid Dynamics for Predicting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Study Protocol for a Multicenter Prospective Study

  • Masato ShibaEmail author
  • Fujimaro Ishida
  • Fumitaka Miya
  • Tomohiro Araki
  • Mitsuhito Mase
  • Hiroki Kurita
  • Hidetoshi Kasuya
  • Takuji Yamamoto
  • Yoko Kato
  • Satoshi Iwabuchi
  • Hidenori Suzuki
  • CFD3 Study Group
Chapter
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 127)

Abstract

Background: Delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Recently, we reported the possibility that computational fluid dynamics (CFD) could predict DCI in terms of the cross-sectional area and flow velocity of the ipsilateral extracranial internal carotid and distal parent arteries in a single-center retrospective study.

Methods: This is a multicenter, prospective, cohort study. Patients with aneurysmal SAH will undergo CFD analyses using preoperative three-dimensional computed tomography angiography, and we will investigate hemodynamic features of cerebral arteries in an acute stage of SAH. Primary outcome measures will be CFD features in patients with subsequent occurrence of DCI. Secondary outcome measures will be CFD features in patients with subsequent occurrence of cerebral vasospasm and cerebral infarction and the relationships with eventual modified Rankin scale score at 3 months.

Conclusions: The present protocol for a multicenter prospective study is expected to provide a novel diagnostic method to predict DCI before aneurysmal obliteration in an acute stage of SAH.

Keywords

Subarachnoid hemorrhage Delayed cerebral ischemia Cerebral aneurysm Computational fluid dynamics Computed tomography angiography 

Notes

Acknowledgments

This study is supported in part by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science to Drs. Shiba and Suzuki.

Conflict of Interest: The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Masato Shiba
    • 1
    Email author
  • Fujimaro Ishida
    • 2
  • Fumitaka Miya
    • 3
  • Tomohiro Araki
    • 4
  • Mitsuhito Mase
    • 5
  • Hiroki Kurita
    • 6
  • Hidetoshi Kasuya
    • 7
  • Takuji Yamamoto
    • 8
  • Yoko Kato
    • 9
  • Satoshi Iwabuchi
    • 10
  • Hidenori Suzuki
    • 1
  • CFD3 Study Group
  1. 1.Department of NeurosurgeryMie University Graduate School of MedicineTsuJapan
  2. 2.Department of NeurosurgeryMie Central Medical CenterTsuJapan
  3. 3.Department of NeurosurgeryIse Red Cross HospitalIseJapan
  4. 4.Department of NeurosurgerySuzuka Kaisei HospitalSuzukaJapan
  5. 5.Department of NeurosurgeryNagoya City University Graduate School of MedicineNagoyaJapan
  6. 6.Department of Cerebrovascular SurgerySaitama Medical University International Medical CenterHidakaJapan
  7. 7.Department of NeurosurgeryTokyo Women’s Medical University Medical Center EastTokyoJapan
  8. 8.Department of NeurosurgeryJuntendo University Shizuoka HospitalShizuokaJapan
  9. 9.Department of NeurosurgeryFujita Health University Banbuntane Hotokukai HospitalNagoyaJapan
  10. 10.Department of NeurosurgeryToho University Medical Center Ohashi HospitalTokyoJapan

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