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Transcranial Doppler Ultrasound, Perfusion Computerized Tomography, and Cerebral Angiography Identify Different Pathological Entities and Supplement Each Other in the Diagnosis of Delayed Cerebral Ischemia

  • Caroline Dietrich
  • Jasper van Lieshout
  • Igor Fischer
  • Marcel A. Kamp
  • Jan F. Cornelius
  • Angelo Tortora
  • Hans Jakob Steiger
  • Athanasios K. Petridis
Chapter
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 127)

Abstract

Introduction: There is still controversial discussion of the value of transcranial Doppler (TCD) in predicting vasospasms in patients with aneurysmal SAH (aSAH). A newer method of predicting a delayed ischemic deficit (DCI) is CT perfusion (CTP), although it is not quite understood which kind of perfusion deficit is detected by this method since it seems to also identifying microcirculatory disturbances. We compared the TCD and CTP values with angiography and evaluated TCD and CTP changes before and after patients received intra-arterial spasmolytic therapy.

Material and Methods: Retrospective analysis of TCD, CTP, and angiographies of N = 77 patients treated from 2013 to 2016. In 38 patients intra-arterial spasmolysis had been performed, and in these cases TCD and CTP data were compared before and after lysis. Thirty-nine patients had a pathological CTP but no angiographically seen vasospasm.

Results: There was no correlation between the known thresholds of mean transit time (MTT) in CTP and vasospasm or with mean velocities in TCD and vasospasm. After spasmolysis in patients with vasospasms, only the MTT showed significant improvement, whereas TCD velocities and Lindegaard index remained unaffected.

Conclusion: TCD and CTP seem to identify different pathological entities of DCI and should be used supplementary in order to identify as many patients as possible with vasospasms after aSAH.

Keywords

Aneurysmal subarachnoid hemorrhage Perfusion computed tomography Transcranial Doppler ultrasonography Angiography Vasospasm 

Notes

Conflict of Interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Funding: No funding was received for this research.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Caroline Dietrich
    • 1
  • Jasper van Lieshout
    • 2
  • Igor Fischer
    • 2
  • Marcel A. Kamp
    • 2
  • Jan F. Cornelius
    • 2
  • Angelo Tortora
    • 2
  • Hans Jakob Steiger
    • 2
  • Athanasios K. Petridis
    • 3
  1. 1.Institute of Radiology, University Hospital Duesseldorf, Heinrich Heine University DuesseldorfDuesseldorfGermany
  2. 2.Department of NeurosurgeryUniversity Hospital Duesseldorf, Heinrich Heine University DuesseldorfDuesseldorfGermany
  3. 3.Department of NeurosurgeryHeinrich Heine University DuesseldorfDuesseldorfGermany

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