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Subarachnoid Hemorrhage Pattern Predicts Acute Cerebral Blood Flow Response in the Rat

  • Jesse J. Liu
  • Jeffrey S. Raskin
  • Robin McFarlane
  • Ravi Samatham
  • Justin S. CetasEmail author
Chapter
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 127)

Abstract

There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.

Keywords

Subarachnoid hemorrhage P450 eicosanoids 20-HETE 14,15-EET Cortical spreading depolarization Early brain injury Stroke glymphatic 

Notes

Acknowledgments

This work was supported by the Veterans Administration Merit # 5I01 BX001659-03 from the US Department of Veterans Affairs.

Conflict of Interest: The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Jesse J. Liu
    • 1
  • Jeffrey S. Raskin
    • 1
  • Robin McFarlane
    • 2
  • Ravi Samatham
    • 1
  • Justin S. Cetas
    • 1
    • 2
    Email author
  1. 1.Department of Neurological SurgeryOregon Health & Science UniversityPortlandUSA
  2. 2.Portland VA Medical CenterPortlandUSA

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