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Ocular Complications of Targeted Therapy

  • Ashley Neiweem
  • Denis Jusufbegovic
  • Arun D. Singh
Chapter

Abstract

The field of oncology is a rapidly enhancing one, with transition from traditional cytotoxic chemotherapeutic agents to molecularly targeted therapies for the treatment of a variety of cancers. Novel targeted therapies are selected and designed through cellular signaling pathways necessary for growth and survival of neoplastic cells to provide maximal antitumor effect with minimal alteration of normal cellular function. However, the complexity of cellular pathways proves difficult to design therapeutic agents that do not overlap with the physiologic activities of normal human cellular function. As novel molecularly targeted therapies continue to emerge in the clinical setting, defining prevalence and characteristics of their side effects becomes important for the ophthalmologist to recognize and effectively manage in this patient population when presented with ocular complaints.

Keywords

Oncology Ophthalmology Ocular side effects Molecular targeted therapy Ocular toxicity Cellular signaling pathway Kinase inhibitor Cellular signaling pathway inhibitor Growth factor receptor inhibitor Immunotherapy MEK inhibitors 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ashley Neiweem
    • 1
  • Denis Jusufbegovic
    • 1
  • Arun D. Singh
    • 2
  1. 1.Department of OphthalmologyIndiana University School of Medicine/Glick Eye InstituteIndianapolisUSA
  2. 2.Department of Ophthalmic OncologyCole Eye Institute, Cleveland ClinicClevelandUSA

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