Chemistry and Pharmacology of Guggulsterone: An Active Principle of Guggul Plant

  • Musadiq Hussain Bhat
  • Mufida Fayaz
  • Amit Kumar
  • Ashok Kumar Jain


Guggulsterone is a plant sterol isolated from gum resin of some members of family Burseraceae. The gum resin from these plants has been used for thousands of years to treat various ailments like obesity, tumours, intestinal worms, liver problems, cancer, leucoderma, etc. An important bioactive component of this natural resin has been identified as guggulsterone. There is a great demand for large amounts of the guggulsterones for further in vitro and in vivo studies. As this demand is not met by natural sources, which only provide the compounds in low yield, synthetic mechanisms were recently developed for synthesis of this important sterol to make it available in sufficient quantities to put in evidence its valuable biological effects. The aim of this review is to examine the chemistry and pharmacology of this compound.


Guggulsterone Anti-inflammatory Anticancer Steroids Commiphora 



B-cell lymphoma 2




Dimethyl sulfoxide


Dextran sulfate sodium


Farnesoid X receptor




Head and neck squamous carcinoma


Inhibitor of apoptosis proteins






Inducible nitric oxide synthase


c-Jun NH(2)-terminal kinase




Mitogen-activated protein kinase associated protein 1


Myeloid cell leukemia 1


Mammalian target of rapamycin


Nuclear factor-kB




Vascular endothelial growth factor


Vascular endothelial growth factor receptor


X-linked inhibitor of apoptosis protein


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Musadiq Hussain Bhat
    • 1
  • Mufida Fayaz
    • 1
  • Amit Kumar
    • 2
  • Ashok Kumar Jain
    • 2
  1. 1.School of Studies in BotanyJiwaji UniversityGwaliorIndia
  2. 2.Institute of Ethnobiology, Jiwaji UniversityGwaliorIndia

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