Design of a Label-Free Multiplexed Biosensing Platform Based on an Ultracompact Plasmonic Resonant Cavity
A multi-analyte biosensing platform for the selective label-free detection of protein biomarkers has been designed through a three-dimensional model based on the finite element method. The sensing element of the platform is a planar plasmonic nanocavity, consisting of a one-dimensional periodic structure (Bragg grating) in gold, with a defect, placed on the buried oxide of a silicon-on-insulator substrate. The footprint of this sensing element, which has a good chemical stability, is only 1.57 μm2. The sensor has a detection limit of 128 pg/mm2 and a surface sensitivity of 1.8 nm/nm.
KeywordsBiosensor Plasmonics Bragg grating
- 12.Dell’Olio, F., De Palo, M., Conteduca, D., Ciminelli, C.: Resonant nanoplasmonic platform for fast and early diagnosis of cardiovascular diseases. In: Proceedings of the IEEE 2nd International Forum on Research and Technologies for Society and Industry Leveraging a better tomorrow (RTSI), pp. 1–4. IEEE, New York (2016)Google Scholar
- 14.Maier, S.A.: Plasmonics: fundamentals and applications. Springer, New York (2006)Google Scholar