Advertisement

A Molecularly Imprinted Polymer on a Novel Surface Plasmon Resonance Sensor

  • Maria PesaventoEmail author
  • Simone Marchetti
  • Luigi Zeni
  • Nunzio Cennamo
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 539)

Abstract

As a proof of principle, we have developed a novel surface plasmon resonance (SPR) sensor used to monitor the interaction between a molecularly imprinted polymer (MIP) and a small molecule as the substrate. This plasmonic platform is based on a removable polymethyl methacrylate (PMMA) chip with a thin gold film on the top, two PMMA plastic optical fibers (POFs) and a special holder, designed to obtain the plasmonic phenomenon. We have experimentally tested whether the optical sensitivity is sufficient for monitoring an MIP receptor. The advantage of MIPs is that they can be directly deposited on a flat gold surface by a spin coater machine, without modifying the surface, as needed for the bio-receptors. With this new sensor, it is possible to achieve remote sensing capabilities, by POFs, and also to realize an engineered platform with a removable chip sensor.

Keywords

Surface plasmon resonance sensors Molecularly imprinted polymers Slab waveguides 

References

  1. 1.
    Sharma, A.K., Jha, R., Gupta, B.D.: Fiber-optic sensors based on surface plasmon resonance: a comprehensive review. IEEE Sens. J. 7, 1118–1129 (2007)CrossRefGoogle Scholar
  2. 2.
    Homola, J.: Present and future of surface plasmon resonance biosensors. Anal. Bioanal. Chem. 377, 528–539 (2003)CrossRefGoogle Scholar
  3. 3.
    Caucheteur, C., Guo, T., Albert, J.: Review of plasmonic fiber optic biochemical sensors: improving the limit of detection. Anal. Bioanal. Chem. 407(14), 3883–3897 (2015)CrossRefGoogle Scholar
  4. 4.
    Cennamo, N., Mattiello, F., Zeni, L.: Slab waveguide and optical fibers for novel plasmonic sensor configurations. Sensors 17, 1488 (2017)CrossRefGoogle Scholar
  5. 5.
    Cennamo, N., De Maria, L., D’Agostino, G., Zeni, L., Pesavento, M.: Monitoring of low levels of furfural in power transformer oil with a sensor system based on a POF-MIP platform. Sensors 15, 8499–8511 (2015)CrossRefGoogle Scholar
  6. 6.
    Uzun, L., Turner, A.P.F.: Molecularly-imprinted polymers sensors: realising their potential. Biosens. Bioelectron. 76, 131–144 (2016)CrossRefGoogle Scholar
  7. 7.
    Camara, J.S., Alves, M.A., Marques, J.C.: Changes in volatile composition of madeira wines during their oxidative ageing. Anal. Chim. Acta 563, 188–197 (2006)CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Maria Pesavento
    • 1
    Email author
  • Simone Marchetti
    • 1
  • Luigi Zeni
    • 2
  • Nunzio Cennamo
    • 2
  1. 1.Department of ChemistryUniversity of PaviaPaviaItaly
  2. 2.Department of EngineeringUniversity of Campania L. VanvitelliAversaItaly

Personalised recommendations