Demyelinating Disease and Pregnancy

  • Tamara B. KaplanEmail author
  • Riley Bove


Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) are chronic inflammatory disorders of the central nervous system that often affect women during their childbearing years. Therefore, many patients and providers navigate pregnancy-related management decisions. The current review provides updated information on the clinical effects of pregnancy on MS and NMO course, as well as the available data on safety of immunomodulatory MS treatments for pregnant and lactating women. We also address broader management issues of women with MS and NMO during conception, gestation and the postpartum period.


Multiple sclerosis Neuromyelitis optica Demyelinating disease Relapse Disease modifying therapy Pregnancy  Lactation Disability 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Neurology, Harvard Medical SchoolBrigham and Women’s HospitalBostonUSA
  2. 2.Department of Neurology, Weill Institute for the NeurosciencesUniversity of CaliforniaSan FranciscoUSA

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