Infectious Agents Associated with Mesothelioma

  • Nguyen Son Lam
  • Nguyen Van Tho
  • Tran Dinh Thanh
  • Yasutaka Nakano
Part of the Current Cancer Research book series (CUCR)


Malignant mesothelioma is a rare but fatal disease which arises from the epithelial lining of the pleura, peritoneum, pericardium, and tunica vaginalis. Malignant pleural mesothelioma (MPM) is the most common form. The global incidence of MPM has risen steadily over the past decade and is predicted to peak in 2020. The mechanism of carcinogenesis in MPM is multifactorial. A history of long-term exposure to asbestos is the established cause of MPM. Cytolysins such as Pneumolysin, Streptolysin O, Intermedilysin, Mitilysin, and Lectinolysin secreted by the airways microbiota may create pores through which asbestos can pass through the airways, reach the visceral pleura and cause MPM. However, MPM may result from other factors such as genetics, erionite, chest wall radiation, and simian virus 40 (SV40) that may work alone or in combination. The roles of SV40 in malignant mesothelioma is still controversial. More studies are needed to explain the wide disparity in the prevalence of SV40 in mesothelioma tissues reported by different laboratories or regions. In this chapter we discuss about how infectious agents may be associated with malignant mesothelioma.


Immunohistochemistry Malignant mesothelioma Pleural Simian virus 40 Tumor Viral carcinogenesis Viral infection 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nguyen Son Lam
    • 1
  • Nguyen Van Tho
    • 2
  • Tran Dinh Thanh
    • 3
  • Yasutaka Nakano
    • 4
  1. 1.Department of PathologyPham Ngoc Thach HospitalHo Chi Minh CityVietnam
  2. 2.Department of Tuberculosis and Lung Diseases, Faculty of MedicineUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam
  3. 3.Department of OncologyPham Ngoc Thach HospitalHo Chi Minh CityVietnam
  4. 4.Division of Respiratory Medicine, Department of MedicineShiga University of Medical ScienceShigaJapan

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