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Ependymoma in the Children

  • Shobhan Vachhrajani
  • Corey RaffelEmail author
Chapter

Abstract

Ependymomas are rare tumors of neuroectodermal origin. Pediatric ependymomas, the focus of this chapter, are found primarily intracranially. Two-thirds of these are found infratentorially. Surgical resection remains the foundation of therapy for these tumors, and surgeons have to balance the goals of complete resection with minimizing postoperative neurological deficit given adherence to vital neurologic structures. Radiation is a commonly employed adjuvant therapy and is the standard of care for posterior fossa ependymomas in children. Chemotherapy continues to show little benefit for this disease. A new molecular classification has been recently validated and holds great promise for the accurate diagnosis and management of pediatric ependymoma, with potential for novel therapeutic targets that may improve prognosis in an otherwise difficult to manage tumor.

Keywords

Ependymoma Pediatric Posterior fossa Brain tumor Molecular classification Tumor genetics Surgery Radiation therapy 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryDayton Children’s HospitalDaytonUSA
  2. 2.Boonshoft School of MedicineWright State UniversityDaytonUSA
  3. 3.Department of Neurological SurgeryUniversity of California, San FranciscoSan FranciscoUSA

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