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Current Therapy of Chronic Hepatitis C Virus in Treatment-Naive Patients

  • Alhareth AlJuboori
  • Satinder Kaur
  • Veysel TahanEmail author
Chapter

Abstract

Hepatitis C virus (HCV) is one of the most commonly transmitted blood-borne diseases in the United States and the world with a high percentage of infected individuals leading to persistent infection and progression of hepatic inflammation. Patients who fail to clear the virus spontaneously will develop chronic HCV, ultimately leading to the development of cirrhosis in 10–20% of patients over the following 2–3 decades. The goal of therapy is to prevent HCV-related complications with early detection and prevention to substantially impact the prognosis. Liver biopsy remains the gold standard for staging fibrosis but, with recent advances in noninvasive methods, serum biomarkers and imaging techniques can be utilized first to avoid complications from biopsy. Given recent advances in treatment options with direct-acting antivirals (DAAs), data shows increased SVR rates, along with simpler regimens and less severe side effect profiles.

Keywords

Hepatitis C virus Direct-acting antivirals Sustained virological response Cirrhosis FibroScan 

Notes

Acknowledgment

Disclosure: Nothing to disclose.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alhareth AlJuboori
    • 1
  • Satinder Kaur
    • 2
  • Veysel Tahan
    • 1
    Email author
  1. 1.Department of Internal Medicine, Division of Gastroenterology and HepatologyUniversity of Missouri School of MedicineColumbiaUSA
  2. 2.Department of Internal Medicine, VA Sierra Nevada Health Care SystemUniversity of Nevada School of MedicineRenoUSA

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