Exploring the Benefits of Endophytic Fungi via Omics

  • Hasnahana Chetia
  • Debajyoti Kabiraj
  • Biju Bharali
  • Sunita Ojha
  • Manash Pratim Barkataki
  • Dharitri Saikia
  • Tinka Singh
  • Ponnala Vimal Mosahari
  • Pragya Sharma
  • Utpal BoraEmail author
Part of the Fungal Biology book series (FUNGBIO)


Endophytic fungi constitute a remarkably diverse, ubiquitous group of eukaryotes with the ability to synthesize secondary metabolites of clinical significance. Their presence has an advantageous effect on growth and health of host plants under duress. They have also been envisaged as a source of diverse medicinal compounds since the discovery of taxol, a prominent anti-cancer drug. In this chapter, we have discussed how resident endophytic fungi aids the host plant in tackling various forms of biotic and abiotic stresses. Their therapeutic potential, viz. cancer cytotoxicity, immunomodulatory, anti-parasitic and anti-pathogenic potential have also been reviewed here. This chapter also explores the plethora of literature available for genomics, metagenomics, transcriptomics, proteomics and metabolomics of endophytic fungi alongside their available web-resources. Applications of omics-based studies on these mutualistic biotrophs have been instrumental in discovery of many unanswered and novel aspects of their biosynthetic potential and overall biology. Data reservoir on fungal endophytes has been constantly growing over the past decades and this reservoir can pave the route of future exploration of these beneficial organisms in therapeutics, biology and evolution via emergent and evolving modes of analysis like machine learning and more.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Hasnahana Chetia
    • 1
  • Debajyoti Kabiraj
    • 1
  • Biju Bharali
    • 2
  • Sunita Ojha
    • 1
  • Manash Pratim Barkataki
    • 1
  • Dharitri Saikia
    • 2
  • Tinka Singh
    • 2
  • Ponnala Vimal Mosahari
    • 2
  • Pragya Sharma
    • 3
  • Utpal Bora
    • 1
    • 2
    Email author
  1. 1.Department of Biosciences and BioengineeringIndian Institute of Technology GuwahatiGuwahatiIndia
  2. 2.Centre for the EnvironmentIndian Institute of Technology GuwahatiGuwahatiIndia
  3. 3.Department of Bioengineering and Technology, Gauhati University Institute of Science and Technology (GUIST)Gauhati UniversityGuwahatiIndia

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