Models for Fully-Activated Muscle

  • David Aitchison Smith


Having surveyed the mechanics and biochemistry of striated muscle, the next step is to formulate theories and models of contractility at full calcium-activation, based on the unit cell of the lattice in one half-sarcomere. To construct a robust and comprehensive theory, Huxley’s model can be updated to include physically motivated strain-dependent kinetics, the working stroke and simplified forms of the biochemical contraction cycle. Starting with the application of Kramers-Smoluchowski theory to strain-dependent transitions in the biochemical cycle, we survey vernier and lattice models of contraction, computational methods, the effects of filament compliance, and models with multiple actin sites and buckling rods. Then these models are tested against experiment for their steady-state contractile behaviour, including the effects of changing [ADP], [Pi], [ATP] and temperature.


Strain Working stroke Contraction cycle Tension ATPase Efficiency 


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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • David Aitchison Smith
    • 1
  1. 1.Department of Physiology, Anatomy and MicrobiologyLa Trobe UniversityMelbourneAustralia

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