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Molecular Biology of EBV in Relationship to HIV/AIDS-Associated Oncogenesis

  • Fengchao Lang
  • Yonggang Pei
  • Zachary L. Lamplugh
  • Erle S. Robertson
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 177)

Abstract

Herpesvirus-induced disease is one of the most lethal factors which leads to high mortality in HIV/AIDS patients. EBV, also known as human herpesvirus 4, can transform naive B cells into immortalized cells in vitro through the regulation of cell cycle, cell proliferation, and apoptosis. EBV infection is associated with several lymphoma and epithelial cancers in humans, which occurs at a much higher rate in immune deficient individuals than in healthy people, demonstrating that the immune system plays a vital role in inhibiting EBV activities. EBV latency infection proteins can mimic suppression cytokines or upregulate PD-1 on B cells to repress the cytotoxic T cells response. Many malignancies, including Hodgkin Lymphoma and non-Hodgkin’s lymphomas occur at a much higher frequency in EBV positive individuals than in EBV negative people during the development of HIV infection. Importantly, understanding EBV pathogenesis at the molecular level will aid the development of novel therapies for EBV-induced diseases in HIV/AIDS patients.

Keywords

EBV HIV/AIDS Oncogenesis Latent infection Lymphoma 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Fengchao Lang
    • 1
    • 2
  • Yonggang Pei
    • 1
    • 2
  • Zachary L. Lamplugh
    • 1
    • 2
  • Erle S. Robertson
    • 1
    • 2
    • 3
  1. 1.Department of Otorhinolaryngology–Head and Neck Surgery and Tumor Virology and Global Cancer ProgramsAbramson Cancer CenterPhiladelphiaUSA
  2. 2.Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.PhiladelphiaUSA

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