• Vladimir V. Klimov


Vaccination leads to the artificial immunity not entirely analogous to natural immune memory and herd immunity. The reader can find medical principles of immunization including recommended schedule, indications, contraindications, side effects and emergency procedures, types of vaccines, and strategies for the development of new vaccines.

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  1. Bernasconi V, Norling K, Bally M, Hook F, Lycke NY. Mucosal vaccine development based on liposome technology. J Immunol Res. 2016;5482087:1–16. Scholar
  2. Erlewyn-Lajeunesse M, Bonhoeffer J, Ruggeberg JU, Heath PT. Anaphylaxis as an adverse event following immunisation. J Clin Pathol. 2007;60:737–9. Scholar
  3. Mahanty S, Prigent A, Garraud O. Immunogenicity of infectious pathogens and vaccine antigens. BMC Immunol. 2015;16(31):1–6. Scholar
  4. Omer SB. Maternal immunization. N Engl J Med. 2017;376:1256–67. Scholar
  5. Smith KA. Louis Pasteur, the father of immunology? Front Immunol. 2012;3(68):1–10. Scholar

Landmark Papers

  1. Siegrist C-A. Vaccine immunology. In: Plotkin SA, Orenstein WA, Offit PA, editors. Vaccines. 6th ed. New York: Elsevier Inc.; 2013. p. 14–32. Scholar

Suggested Reading

  1. Anjue’re F, Bekri S, Bihl F, Braud VM, Cuburu N, Czerkinsky C, Hervouet C, Luci C. B cell and T cell immunity in the female genital tract: potential of distinct mucosal routes of vaccination and role of tissue-associated dendritic cells and natural killer cells. Clin Microbiol Infect. 2012;18(5):117–22. Scholar
  2. Ciabattini A, Pettini E, Fiorino F, Pastore G, Andersen P, Pozzi G, Medaglini D. Modulation of primary immune response by different vaccine adjuvants. Front Immunol. 2016;7(427):1–12. Scholar
  3. Centlivre M, Combadiere B. New challenges in modern vaccinology. BMC Immunol. 2015;16(18):1–6. Scholar
  4. Leo L, Cunningham A, Stern PL. Vaccine immunology. Perspect Vaccinol. 2011;1(1):25–59. Scholar
  5. Ogra PL, Faden H, Welliver RC. Vaccination strategies for mucosal immune responses. Clin Microbiol Rev. 2001;14(2):430–45.–445.2001.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Srivastava A, Gowda DV, Madhunapantula SV, Shinde CG, Iyer M. Mucosal vaccines: a paradigm shift in the development of mucosal adjuvants and delivery vehicles. APMIS. 2015;123(4):275–88. Scholar
  7. Wiley CC. Immunizations: vaccinations in general. Pediatr Rev. 2015;36(6):249–59. Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Vladimir V. Klimov
    • 1
  1. 1.Clinical Immunology and Allergy DepartmentSiberian State Medical UniversityTomskRussia

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