In order to establish a disruptive geography through innovation one should have a clear understanding on the conceptual and theoretical aspects of innovation and geography symbiosis. This part of the book focused on expanding our conceptual and theoretical understanding and relevant aspects associated with innovative growth, cities and economic geography. The old trajectories traceable back to Marshall and Schumpeter are still evident in the current classifications and view-points on how to look at the economic landscape in cities. The latest trajectories include knowledge-based urban development paradigm and knowledge and smart city notions. This chapter provides a concluding remark to this part of the book that focuses on theory of innovation geography.