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Dual-Energy SPECT Imaging with Contrast-Enhanced CT: A Case Study

  • Emily B. Martin
  • Alan Stuckey
  • Stephen J. Kennel
  • Jonathan S. Wall
Chapter

Abstract

Preclinical molecular imaging is an invaluable tool to support the discovery and development of clinically relevant imaging and therapeutic reagents. Single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) are commonly used in clinical nuclear medicine, and these imaging platforms can be utilized in the preclinical setting for discovery, validation, and comparative effectiveness evaluation of novel radiolabeled diagnostic imaging agents. Herein, we discuss these techniques and how we have utilized them to enhance experimental design when evaluating novel radiotracers in vivo. In particular, we focus on the utility of dual-energy SPECT with contrast-enhanced CT and demonstrate how these can be used as exceptional tools for quantitatively and effectively comparing two diagnostic imaging agents.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Emily B. Martin
    • 1
  • Alan Stuckey
    • 1
  • Stephen J. Kennel
    • 1
  • Jonathan S. Wall
    • 1
  1. 1.Department of MedicineUniversity of Tennessee Medical CenterKnoxvilleUSA

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