Neurodevelopmental Outcomes

  • Katherine Lord
  • Diva D. De León-CrutchlowEmail author
Part of the Contemporary Endocrinology book series (COE)


Infants and children with hyperinsulinism are at high risk of brain damage. Multiple studies have demonstrated the increased prevalence of both neurodevelopmental abnormalities (26–48%) and seizures (13–29%) in the hyperinsulinism population. Individuals are at risk of poor neurodevelopmental outcomes regardless of the duration of the hyperinsulinism or treatment modality. All children with hyperinsulinism require screening for developmental issues and swift intervention if abnormalities are identified.


Hyperinsulinism Hypoglycemia Developmental delay Seizures 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Endocrinology and Diabetes, Department of PediatricsPerelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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