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Protons and Heavy Ions

  • A. D. JensenEmail author
  • P. Fossati
Chapter

Abstract

Particle therapy as proton or heavy ion therapy has several dosimetric and biological advantages over photon radiotherapy. To date, access to this treatment modality is limited, and treatment costs are still considerably higher than for standard photon radiotherapy.

However, particle therapy has shown promising results especially in locally advanced salivary gland cancers.

The chapter will provide an overview of physical and biological basics of particle radiotherapy in general and for malignant salivary gland tumours in particular. It will examine and discuss rationale and available clinical evidence for carbon ion and proton therapy in this challenging disease.

Keywords

Particle therapy Protons Carbon ions (C12) 

Abbreviations

ACC

Adenoid cystic carcinoma

ART

Adaptive radiotherapy

BED

Biological effective dose

C12

Carbon ions

CTCAE

Common Terminology Criteria for Adverse Events

EORTC

European Organisation for Research and Treatment of Cancer

ICRU

International Commission on Radiation Units and Measurements

IGRT

Image-guided radiotherapy

IMRT

Intensity-modulated radiotherapy

LEM

Local effects model

LET

Linear energy transfer

MKM

Microdosimetric kinetic model

MRC

Medical Research Council

MSGT

Malignant salivary gland tumour

NTCP

Normal tissue complication probability

OAR

Organ at risk

RBE

Relative biological effectiveness

RTOG

Radiation Therapy Oncology Group

SOBP

Spread-out Bragg peak

VMAT

Volumetric arc therapy

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Radiation Oncology GießenUniversity Hospital Gießen and Marburg (UKGM)MarburgGermany
  2. 2.Fondazione CNAOPaviaItaly
  3. 3.EBG MedAustron GmbHWiener NeustadtAustria

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